STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHA6Pleckstrin homology domain containing A6. (1279 aa)    
Predicted Functional Partners:
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 0.619
VMO1
Vitelline membrane outer layer 1 homolog.
    
 0.484
IRGQ
Immunity related GTPase Q.
   
  
 0.479
STAP1
Signal transducing adaptor family member 1.
      
 0.477
DAB2IP
DAB2 interacting protein.
   
 0.452
DLEC1
DLEC1 cilia and flagella associated protein.
    
 0.451
MVB12B
Multivesicular body subunit 12B.
   
  
 0.446
RHOC
Protein phosphatase, Mg2+/Mn2+ dependent 1J.
      
 0.443
GPR155
G protein-coupled receptor 155.
   
  
 0.443
PPFIA4
PTPRF interacting protein alpha 4.
   
 
 0.441
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.