OCA2 protein (Equus caballus) - STRING interaction network

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Score

OCA2

OCA2 melanosomal transmembrane protein. (838 aa)

Predicted Functional Partners:

SLC24A5

0.934

TYRP1

0.915

ACP1

0.913

SLC45A2

0.910

TYR

0.905

GET3

0.851

CCDC13

0.824

MLANA

0.723

ASIP

0.704

GPR143

0.701

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	GET3	ENSECAP00000008037	ENSECAP00000005353	Acid phosphatase 1.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.911
ACP1	OCA2	ENSECAP00000008037	ENSECAP00000032264	Acid phosphatase 1.	OCA2 melanosomal transmembrane protein.	0.913
ASIP	OCA2	ENSECAP00000003317	ENSECAP00000032264	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	OCA2 melanosomal transmembrane protein.	0.704
ASIP	SLC24A5	ENSECAP00000003317	ENSECAP00000023675	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.513
ASIP	SLC45A2	ENSECAP00000003317	ENSECAP00000032909	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Solute carrier family 45 member 2.	0.494
ASIP	TYR	ENSECAP00000003317	ENSECAP00000014187	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Tyrosinase.	0.777
ASIP	TYRP1	ENSECAP00000003317	ENSECAP00000007884	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Tyrosinase related protein 1.	0.870
CCDC13	OCA2	ENSECAP00000052659	ENSECAP00000032264	Coiled-coil domain containing 13; Belongs to the membrane-bound acyltransferase family.	OCA2 melanosomal transmembrane protein.	0.824
GET3	ACP1	ENSECAP00000005353	ENSECAP00000008037	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Acid phosphatase 1.	0.911
GET3	OCA2	ENSECAP00000005353	ENSECAP00000032264	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	OCA2 melanosomal transmembrane protein.	0.851
GPR143	MLANA	ENSECAP00000008551	ENSECAP00000007027	G protein-coupled receptor 143.	Melan-A.	0.762
GPR143	OCA2	ENSECAP00000008551	ENSECAP00000032264	G protein-coupled receptor 143.	OCA2 melanosomal transmembrane protein.	0.701
GPR143	SLC24A5	ENSECAP00000008551	ENSECAP00000023675	G protein-coupled receptor 143.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.638
GPR143	SLC45A2	ENSECAP00000008551	ENSECAP00000032909	G protein-coupled receptor 143.	Solute carrier family 45 member 2.	0.715
GPR143	TYR	ENSECAP00000008551	ENSECAP00000014187	G protein-coupled receptor 143.	Tyrosinase.	0.615
GPR143	TYRP1	ENSECAP00000008551	ENSECAP00000007884	G protein-coupled receptor 143.	Tyrosinase related protein 1.	0.780
MLANA	GPR143	ENSECAP00000007027	ENSECAP00000008551	Melan-A.	G protein-coupled receptor 143.	0.762
MLANA	OCA2	ENSECAP00000007027	ENSECAP00000032264	Melan-A.	OCA2 melanosomal transmembrane protein.	0.723
MLANA	SLC24A5	ENSECAP00000007027	ENSECAP00000023675	Melan-A.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.806
MLANA	SLC45A2	ENSECAP00000007027	ENSECAP00000032909	Melan-A.	Solute carrier family 45 member 2.	0.673