CFAP298 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

CFAP298

Uncharacterized protein. (295 aa)

Predicted Functional Partners:

CFAP300

0.662

TTC12

0.568

PIH1D2

0.567

CFAP20

0.566

DNAAF3

0.495

DNAAF5

0.486

B9D2

0.483

TMEM17

0.481

CEP41

0.478

SPAG1

0.477

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9D2	CFAP20	ENSECAP00000009845	ENSECAP00000008948	B9 domain containing 2.	Cilia and flagella associated protein 20.	0.477
B9D2	CFAP298	ENSECAP00000009845	ENSECAP00000033264	B9 domain containing 2.	Uncharacterized protein.	0.483
B9D2	TMEM17	ENSECAP00000009845	ENSECAP00000029940	B9 domain containing 2.	Transmembrane protein 17.	0.680
CEP41	CFAP20	ENSECAP00000044269	ENSECAP00000008948	Centrosomal protein 41.	Cilia and flagella associated protein 20.	0.476
CEP41	CFAP298	ENSECAP00000044269	ENSECAP00000033264	Centrosomal protein 41.	Uncharacterized protein.	0.478
CFAP20	B9D2	ENSECAP00000008948	ENSECAP00000009845	Cilia and flagella associated protein 20.	B9 domain containing 2.	0.477
CFAP20	CEP41	ENSECAP00000008948	ENSECAP00000044269	Cilia and flagella associated protein 20.	Centrosomal protein 41.	0.476
CFAP20	CFAP298	ENSECAP00000008948	ENSECAP00000033264	Cilia and flagella associated protein 20.	Uncharacterized protein.	0.566
CFAP20	TMEM17	ENSECAP00000008948	ENSECAP00000029940	Cilia and flagella associated protein 20.	Transmembrane protein 17.	0.477
CFAP298	B9D2	ENSECAP00000033264	ENSECAP00000009845	Uncharacterized protein.	B9 domain containing 2.	0.483
CFAP298	CEP41	ENSECAP00000033264	ENSECAP00000044269	Uncharacterized protein.	Centrosomal protein 41.	0.478
CFAP298	CFAP20	ENSECAP00000033264	ENSECAP00000008948	Uncharacterized protein.	Cilia and flagella associated protein 20.	0.566
CFAP298	CFAP300	ENSECAP00000033264	ENSECAP00000034890	Uncharacterized protein.	Cilia and flagella associated protein 300.	0.662
CFAP298	DNAAF3	ENSECAP00000033264	ENSECAP00000046719	Uncharacterized protein.	Uncharacterized protein.	0.495
CFAP298	DNAAF5	ENSECAP00000033264	ENSECAP00000019249	Uncharacterized protein.	Dynein axonemal assembly factor 5.	0.486
CFAP298	PIH1D2	ENSECAP00000033264	ENSECAP00000010096	Uncharacterized protein.	PIH1 domain containing 2.	0.567
CFAP298	SPAG1	ENSECAP00000033264	ENSECAP00000020133	Uncharacterized protein.	Sperm associated antigen 1.	0.477
CFAP298	TMEM17	ENSECAP00000033264	ENSECAP00000029940	Uncharacterized protein.	Transmembrane protein 17.	0.481
CFAP298	TTC12	ENSECAP00000033264	ENSECAP00000037659	Uncharacterized protein.	Tetratricopeptide repeat domain 12.	0.568
CFAP300	CFAP298	ENSECAP00000034890	ENSECAP00000033264	Cilia and flagella associated protein 300.	Uncharacterized protein.	0.662

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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