STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM12ADAM metallopeptidase domain 12. (920 aa)    
Predicted Functional Partners:
VWCE
Von Willebrand factor C and EGF domains.
      
 0.657
SH3PXD2A
SH3 and PX domains 2A.
    
 0.641
MMP9
Matrix metallopeptidase 9.
   
  
 0.582
ITGA11
Integrin subunit alpha 11; Belongs to the integrin alpha chain family.
   
  
 0.484
POMGNT2
Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).
   
  
 0.475
PAPPA
Pappalysin 1.
      
 0.475
HBEGF
Heparin binding EGF like growth factor.
   
  
 0.473
PACSIN3
Protein kinase C and casein kinase substrate in neurons 3.
    
 
 0.464
GRB2
Growth factor receptor bound protein 2.
    
 
 0.463
TIMP3
Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
   
  
 0.452
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.