ANKRD42 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ANKRD42

Ankyrin repeat domain 42. (599 aa)

Predicted Functional Partners:

CCDC90B

0.950

NOB1

0.928

RAB30

0.853

PCF11

0.840

IQUB

0.807

DNAAF1

0.801

ZBBX

0.797

WWP2

0.611

DUSP14

0.595

HSDL2

0.543

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD42	CCDC90B	ENSECAP00000034143	ENSECAP00000011728	Ankyrin repeat domain 42.	Coiled-coil domain containing 90B.	0.950
ANKRD42	DNAAF1	ENSECAP00000034143	ENSECAP00000011428	Ankyrin repeat domain 42.	Dynein assembly factor 1, axonemal.	0.801
ANKRD42	DUSP14	ENSECAP00000034143	ENSECAP00000002577	Ankyrin repeat domain 42.	Dual specificity phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.595
ANKRD42	HSDL2	ENSECAP00000034143	ENSECAP00000036988	Ankyrin repeat domain 42.	Hydroxysteroid dehydrogenase like 2.	0.543
ANKRD42	IQUB	ENSECAP00000034143	ENSECAP00000004183	Ankyrin repeat domain 42.	IQ motif and ubiquitin domain containing.	0.807
ANKRD42	NOB1	ENSECAP00000034143	ENSECAP00000021281	Ankyrin repeat domain 42.	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	0.928
ANKRD42	PCF11	ENSECAP00000034143	ENSECAP00000039712	Ankyrin repeat domain 42.	PCF11 cleavage and polyadenylation factor subunit.	0.840
ANKRD42	RAB30	ENSECAP00000034143	ENSECAP00000020236	Ankyrin repeat domain 42.	Ras-related protein Rab-30-like protein.	0.853
ANKRD42	WWP2	ENSECAP00000034143	ENSECAP00000032813	Ankyrin repeat domain 42.	E3 ubiquitin-protein ligase.	0.611
ANKRD42	ZBBX	ENSECAP00000034143	ENSECAP00000026288	Ankyrin repeat domain 42.	Zinc finger B-box domain containing.	0.797
CCDC90B	ANKRD42	ENSECAP00000011728	ENSECAP00000034143	Coiled-coil domain containing 90B.	Ankyrin repeat domain 42.	0.950
CCDC90B	NOB1	ENSECAP00000011728	ENSECAP00000021281	Coiled-coil domain containing 90B.	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	0.953
CCDC90B	PCF11	ENSECAP00000011728	ENSECAP00000039712	Coiled-coil domain containing 90B.	PCF11 cleavage and polyadenylation factor subunit.	0.806
CCDC90B	RAB30	ENSECAP00000011728	ENSECAP00000020236	Coiled-coil domain containing 90B.	Ras-related protein Rab-30-like protein.	0.902
CCDC90B	WWP2	ENSECAP00000011728	ENSECAP00000032813	Coiled-coil domain containing 90B.	E3 ubiquitin-protein ligase.	0.650
DNAAF1	ANKRD42	ENSECAP00000011428	ENSECAP00000034143	Dynein assembly factor 1, axonemal.	Ankyrin repeat domain 42.	0.801
DUSP14	ANKRD42	ENSECAP00000002577	ENSECAP00000034143	Dual specificity phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Ankyrin repeat domain 42.	0.595
HSDL2	ANKRD42	ENSECAP00000036988	ENSECAP00000034143	Hydroxysteroid dehydrogenase like 2.	Ankyrin repeat domain 42.	0.543
HSDL2	PCF11	ENSECAP00000036988	ENSECAP00000039712	Hydroxysteroid dehydrogenase like 2.	PCF11 cleavage and polyadenylation factor subunit.	0.470
IQUB	ANKRD42	ENSECAP00000004183	ENSECAP00000034143	IQ motif and ubiquitin domain containing.	Ankyrin repeat domain 42.	0.807

page 1 of 2

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.574

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016180

snRNA processing

4 of 26

2.43

2.6

1.15e-05

GO:0034472

snRNA 3-end processing

3 of 20

2.42

1.79

0.00045

GO:0034720

Histone H3-K4 demethylation

2 of 9

2.59

1.0

0.0152

GO:0042135

Neurotransmitter catabolic process

2 of 12

2.47

0.91

0.0223

GO:0006584

Catecholamine metabolic process

2 of 18

2.29

0.81

0.0322

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140682

Histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity

2 of 2

3.25

1.4

0.0030

GO:0097621

Monoamine oxidase activity

2 of 3

3.07

1.4

0.0030

GO:0052596

Phenethylamine:oxygen oxidoreductase (deaminating) activity

2 of 2

3.25

1.4

0.0030

GO:0052595

Aliphatic-amine oxidase activity

2 of 2

3.25

1.4

0.0030

GO:0008131

Primary amine oxidase activity

2 of 3

3.07

1.4

0.0030

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032039

Integrator complex

4 of 17

2.62

3.39

4.09e-07

GO:0005694

Chromosome

5 of 797

1.04

0.6

0.0274

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28450736

(2017) Histone lysine demethylases in mammalian embryonic development.

2 of 13

2.43

0.73

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21251

Integrator complex

4 of 6

3.07

4.0

4.84e-08

CL:9408

Structural constituent of chromatin, and Associated with SET domains

3 of 33

2.21

1.81

0.00033

CL:9464

Histone H2B, and 6-phosphogluconate dehydrogenase, NADP-binding

2 of 5

2.85

1.54

0.0016

CL:9397

Chromatin organization, and Epigenetic regulation of gene expression

4 of 200

1.55

1.31

0.0010

CL:1141

Mixed, incl. Histidine metabolism, and Aldo-keto reductase family 1 member A1

2 of 17

2.32

1.09

0.0098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cmk00360

Phenylalanine metabolism

2 of 10

2.55

1.36

0.0032

cmk00340

Histidine metabolism

2 of 14

2.4

1.35

0.0032

cmk00982

Drug metabolism - cytochrome P450

2 of 17

2.32

1.34

0.0032

cmk00350

Tyrosine metabolism

2 of 20

2.25

1.33

0.0032

cmk00380

Tryptophan metabolism

2 of 33

2.03

1.17

0.0057

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-141333

Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

2 of 2

3.25

1.58

0.0014

MAP-6807505

RNA polymerase II transcribes snRNA genes

4 of 112

1.8

1.53

0.00062

MAP-140179

Amine Oxidase reactions

2 of 6

2.77

1.3

0.0043

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032039

Integrator complex

4 of 17

2.62

3.35

4.90e-07

GOCC:0000785

Chromatin

4 of 210

1.53

1.12

0.0033

GOCC:0000786

Nucleosome

2 of 18

2.29

0.92

0.0203

GOCC:0043229

Intracellular organelle

11 of 7678

0.4

0.3

0.0183

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

3 of 55

1.98

1.47

0.0013

KW-0560

Oxidoreductase

3 of 178

1.47

0.87

0.0133

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04433

SWIRM domain

2 of 5

2.85

1.04

0.0130

PF01266

FAD dependent oxidoreductase

2 of 9

2.59

0.97

0.0170

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002937

Amine oxidase

4 of 12

2.77

3.34

6.52e-07

IPR036188

FAD/NAD(P)-binding domain superfamily

4 of 60

2.07

1.99

0.00011

IPR001613

Flavin amine oxidase

2 of 2

3.25

1.34

0.0038

IPR022712

Beta-Casp domain

2 of 4

2.95

1.19

0.0071

IPR007526

SWIRM domain

2 of 6

2.77

1.09

0.0105

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01027

Beta-Casp domain

2 of 4

2.95

1.38

0.0032

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