STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4166 aa)    
Predicted Functional Partners:
XRCC5
X-ray repair cross complementing 5.
   
 0.994
XRCC6
X-ray repair cross complementing 6.
    
 0.992
DCLRE1C
DNA cross-link repair 1C.
   
 0.988
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.979
LIG4
DNA ligase.
   
 0.971
NHEJ1
Non-homologous end joining factor 1.
    
 0.950
RNF144A
RBR-type E3 ubiquitin transferase.
    
 0.935
RPTOR
Regulatory associated protein of MTOR complex 1.
   
 0.878
RICTOR
RPTOR independent companion of MTOR complex 2.
   
 0.875
MLST8
MTOR associated protein, LST8 homolog.
   
 0.869
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.