CYP2C113 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CYP2C113

Cytochrome P450 2C113; Belongs to the cytochrome P450 family. (490 aa)

Predicted Functional Partners:

CYP3A94

0.956

CYP3A93

0.955

CYP3A89

0.955

CYP7A1

0.942

LOC100062102

0.931

LOC100064020

0.931

LOC100070123

0.931

LOC100064092

0.930

ENSECAP00000038003

0.929

CYP17A1

0.926

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP17A1	CYP2C113	ENSECAP00000008577	ENSECAP00000036670	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	0.926
CYP17A1	CYP3A89	ENSECAP00000008577	ENSECAP00000028090	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein.	0.941
CYP17A1	CYP3A93	ENSECAP00000008577	ENSECAP00000027586	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein.	0.939
CYP17A1	CYP3A94	ENSECAP00000008577	ENSECAP00000013801	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein.	0.941
CYP17A1	CYP7A1	ENSECAP00000008577	ENSECAP00000010830	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.953
CYP2C113	CYP17A1	ENSECAP00000036670	ENSECAP00000008577	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.926
CYP2C113	CYP3A89	ENSECAP00000036670	ENSECAP00000028090	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.955
CYP2C113	CYP3A93	ENSECAP00000036670	ENSECAP00000027586	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.955
CYP2C113	CYP3A94	ENSECAP00000036670	ENSECAP00000013801	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.956
CYP2C113	CYP7A1	ENSECAP00000036670	ENSECAP00000010830	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.942
CYP2C113	ENSECAP00000038003	ENSECAP00000036670	ENSECAP00000038003	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.929
CYP2C113	LOC100062102	ENSECAP00000036670	ENSECAP00000017674	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.931
CYP2C113	LOC100064020	ENSECAP00000036670	ENSECAP00000019511	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.931
CYP2C113	LOC100064092	ENSECAP00000036670	ENSECAP00000050620	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.930
CYP2C113	LOC100070123	ENSECAP00000036670	ENSECAP00000035951	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.931
CYP3A89	CYP17A1	ENSECAP00000028090	ENSECAP00000008577	Uncharacterized protein.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.941
CYP3A89	CYP2C113	ENSECAP00000028090	ENSECAP00000036670	Uncharacterized protein.	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	0.955
CYP3A89	CYP3A93	ENSECAP00000028090	ENSECAP00000027586	Uncharacterized protein.	Uncharacterized protein.	0.949
CYP3A89	CYP3A94	ENSECAP00000028090	ENSECAP00000013801	Uncharacterized protein.	Uncharacterized protein.	0.922
CYP3A89	CYP7A1	ENSECAP00000028090	ENSECAP00000010830	Uncharacterized protein.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.931