DNM1 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

DNM1

Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)

Predicted Functional Partners:

DNM3

0.978

DNM2

0.966

CTTN

0.965

HCLS1

0.963

ITSN2

0.948

SYNJ1

0.925

GAK

0.923

AMPH

0.916

FIS1

0.894

SH3GL2

0.886

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMPH	CTTN	ENSECAP00000026472	ENSECAP00000045577	Amphiphysin.	Cortactin.	0.624
AMPH	DNM1	ENSECAP00000026472	ENSECAP00000036706	Amphiphysin.	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.916
AMPH	DNM2	ENSECAP00000026472	ENSECAP00000020466	Amphiphysin.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.819
AMPH	DNM3	ENSECAP00000026472	ENSECAP00000019098	Amphiphysin.	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.443
AMPH	HCLS1	ENSECAP00000026472	ENSECAP00000013412	Amphiphysin.	Hematopoietic cell-specific Lyn substrate 1.	0.641
AMPH	ITSN2	ENSECAP00000026472	ENSECAP00000023079	Amphiphysin.	Intersectin 2.	0.650
AMPH	SH3GL2	ENSECAP00000026472	ENSECAP00000008025	Amphiphysin.	SH3 domain containing GRB2 like 2, endophilin A1.	0.569
AMPH	SYNJ1	ENSECAP00000026472	ENSECAP00000004703	Amphiphysin.	Synaptojanin 1.	0.825
CTTN	AMPH	ENSECAP00000045577	ENSECAP00000026472	Cortactin.	Amphiphysin.	0.624
CTTN	DNM1	ENSECAP00000045577	ENSECAP00000036706	Cortactin.	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.965
CTTN	DNM2	ENSECAP00000045577	ENSECAP00000020466	Cortactin.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.994
CTTN	DNM3	ENSECAP00000045577	ENSECAP00000019098	Cortactin.	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.945
CTTN	GAK	ENSECAP00000045577	ENSECAP00000021630	Cortactin.	Cyclin G associated kinase.	0.412
CTTN	HCLS1	ENSECAP00000045577	ENSECAP00000013412	Cortactin.	Hematopoietic cell-specific Lyn substrate 1.	0.922
CTTN	ITSN2	ENSECAP00000045577	ENSECAP00000023079	Cortactin.	Intersectin 2.	0.630
DNM1	AMPH	ENSECAP00000036706	ENSECAP00000026472	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Amphiphysin.	0.916
DNM1	CTTN	ENSECAP00000036706	ENSECAP00000045577	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Cortactin.	0.965
DNM1	DNM2	ENSECAP00000036706	ENSECAP00000020466	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.966
DNM1	DNM3	ENSECAP00000036706	ENSECAP00000019098	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.978
DNM1	FIS1	ENSECAP00000036706	ENSECAP00000029503	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.894

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.863

expected number of edges:

12

PPI enrichment p-value:

0.000464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033108

Mitochondrial respiratory chain complex assembly

7 of 47

1.95

3.64

2.62e-09

GO:0033617

Mitochondrial cytochrome c oxidase assembly

5 of 29

2.01

2.69

2.00e-06

GO:0007005

Mitochondrion organization

9 of 274

1.29

1.84

5.45e-08

GO:0065003

Protein-containing complex assembly

8 of 488

0.99

0.95

0.00011

GO:0016043

Cellular component organization

10 of 1889

0.5

0.35

0.0153

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005507

Copper ion binding

4 of 22

2.04

1.91

0.00015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

9 of 69

1.89

4.65

1.55e-13

GO:0005740

Mitochondrial envelope

10 of 466

1.11

1.46

1.23e-08

GO:0005743

Mitochondrial inner membrane

5 of 269

1.05

0.78

0.0042

GO:0031966

Mitochondrial membrane

6 of 422

0.93

0.72

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33498264

(2021) Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

6 of 16

2.35

3.81

2.66e-08

PMID:18761382

(2009) Redox regulation of protein folding in the mitochondrial intermembrane space.

6 of 34

2.02

2.89

6.77e-07

PMID:28886682

(2017) Copper Acquisition and Utilization in Fungi.

6 of 36

2.0

2.86

6.77e-07

PMID:34557489

(2021) Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

6 of 47

1.88

2.56

2.01e-06

PMID:29495437

(2018) The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.

5 of 25

2.08

2.44

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2974

Respiratory chain complex IV assembly, and Heme a metabolic process

9 of 18

2.48

8.1

5.75e-18

CL:2995

Mixed, incl. CHCH domain, and Cytochrome c oxidase biogenesis protein Cmc1 like

4 of 6

2.6

3.49

2.57e-07

CL:2977

Copper chaperone activity, and Cytochrome oxidase c subunit VIb

3 of 5

2.56

2.32

4.72e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 59

1.91

4.21

1.45e-11

GOCC:1902695

Metallochaperone complex

3 of 4

2.65

2.52

2.12e-05

GOCC:0005740

Mitochondrial envelope

9 of 368

1.17

1.52

1.20e-07

GOCC:0005739

Mitochondrion

10 of 851

0.85

0.87

2.70e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

8 of 97

1.69

3.31

1.73e-10

KW-0186

Copper

4 of 27

1.95

2.29

1.50e-05

KW-0496

Mitochondrion

10 of 807

0.87

0.91

1.36e-06

KW-0999

Mitochondrion inner membrane

4 of 213

1.05

0.6

0.0273

KW-0143

Chaperone

3 of 105

1.23

0.6

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08583

Cytochrome c oxidase biogenesis protein Cmc1 like

2 of 2

2.78

1.06

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013892

Cytochrome c oxidase biogenesis protein Cmc1-like

2 of 2

2.78

0.78

0.0390

IPR009069

Cysteine alpha-hairpin motif superfamily

2 of 3

2.6

0.78

0.0390

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