STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC111768487Uncharacterized protein. (155 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.914
RELA
RELA proto-oncogene, NF-kB subunit.
   
 
 0.903
JUN
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
     
 0.900
LOC100064703
Uncharacterized protein.
   
 
 
0.685
DEFA1
Alpha-defensin 1; Has broad-spectrum antimicrobial properties. The antimicrobial activity decreases in the present of salt in vitro. Binds anionic phospholipids, which leads to the aggregation of liposomes in vitro. Membrane permeabilization of the target cells is an essential part of the peptide's mode of antimicrobial activity. No hemolytic activity against sheep or horse erythrocytes. Has antibacterial activity against the bacterial horse pathogens Gram-positive R.equi ATCC 33701 P(-) (minimum bactericidal concentration or MBC=5 ug/ml) and R.equi ATCC 33701 P(+) (MBC=5 ug/ml), which [...]
   
  
 0.616
LCN2
Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.586
DQA-2
Ig-like domain-containing protein; Belongs to the MHC class II family.
   
 
 0.536
DEFB1
Defensin beta 1.
      
 0.507
HLA-DOA
Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.
   
   0.462
S100A12
Protein S100; Belongs to the S-100 family.
   
 
 0.449
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.