STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)    
Predicted Functional Partners:
MCL1
MCL1 apoptosis regulator, BCL2 family member.
   
 0.991
BCL2L1
BCL2 like 1.
    
 0.981
BCL2L11
BCL2 like 11.
    
 0.958
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
 0.927
GLMP
Glycosylated lysosomal membrane protein.
    
 0.878
BCL2
BCL2 apoptosis regulator.
    
 0.824
BAK1
BCL2 antagonist/killer 1.
    
 0.796
BBC3
BCL2 binding component 3.
      
 0.792
BAX
BCL2 associated X, apoptosis regulator.
    
 0.716
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.706
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.