STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSECAP00000041724Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (272 aa)    
Predicted Functional Partners:
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.
      
 0.698
CD69
CD69 molecule.
    
 0.602
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.
      
 0.574
FOXP3
Forkhead box P3.
      
 0.566
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
  
 0.564
LOC100050711
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
   
0.536
LOC106782834
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.533
KLRG1
Killer cell lectin like receptor G1.
   
 0.517
PRSS48
Serine protease 48; Belongs to the peptidase S1 family.
  
     0.514
LOC111768663
Peptidase S1 domain-containing protein.
  
   
0.508
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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