STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT20Keratin 20; Belongs to the intermediate filament family. (455 aa)    
Predicted Functional Partners:
UPK1A
Tetraspanin.
      
 0.721
UPK3A
Uroplakin 3A.
      
 0.711
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.701
UPK2
Uroplakin 2.
    
 0.692
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
    
 0.622
CDX2
Caudal type homeobox 2.
   
  
 0.580
UPK1B
Tetraspanin.
   
  
 0.564
CHGA-2
Chromogranin A.
      
 0.512
CTNNB1
Beta catenin 1.
   
 0.502
CHGA
p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
      
 0.502
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.