ENSECAP00000042469 protein (Equus caballus) - STRING interaction network

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Score

ENSECAP00000042469

LAM_G_DOMAIN domain-containing protein. (205 aa)

Predicted Functional Partners:

ARL1

0.619

VRK2

0.493

VRK1

0.493

PPP2R2B

0.493

PPP2R2A

0.493

TP53BP1

0.474

ATM

0.474

MDC1

0.469

PAXIP1

0.469

PPP2CB

0.463

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL1	ENSECAP00000042469	ENSECAP00000054015	ENSECAP00000042469	ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family.	LAM_G_DOMAIN domain-containing protein.	0.619
ATM	ENSECAP00000042469	ENSECAP00000025893	ENSECAP00000042469	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LAM_G_DOMAIN domain-containing protein.	0.474
ATM	MDC1	ENSECAP00000025893	ENSECAP00000009219	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mediator of DNA damage checkpoint 1.	0.981
ATM	PAXIP1	ENSECAP00000025893	ENSECAP00000015728	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.823
ATM	TP53BP1	ENSECAP00000025893	ENSECAP00000006683	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.967
ENSECAP00000042469	ARL1	ENSECAP00000042469	ENSECAP00000054015	LAM_G_DOMAIN domain-containing protein.	ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family.	0.619
ENSECAP00000042469	ATM	ENSECAP00000042469	ENSECAP00000025893	LAM_G_DOMAIN domain-containing protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.474
ENSECAP00000042469	MDC1	ENSECAP00000042469	ENSECAP00000009219	LAM_G_DOMAIN domain-containing protein.	Mediator of DNA damage checkpoint 1.	0.469
ENSECAP00000042469	PAXIP1	ENSECAP00000042469	ENSECAP00000015728	LAM_G_DOMAIN domain-containing protein.	PAX interacting protein 1.	0.469
ENSECAP00000042469	PPP2CB	ENSECAP00000042469	ENSECAP00000009288	LAM_G_DOMAIN domain-containing protein.	Serine/threonine-protein phosphatase.	0.463
ENSECAP00000042469	PPP2R2A	ENSECAP00000042469	ENSECAP00000041416	LAM_G_DOMAIN domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.493
ENSECAP00000042469	PPP2R2B	ENSECAP00000042469	ENSECAP00000039692	LAM_G_DOMAIN domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.493
ENSECAP00000042469	TP53BP1	ENSECAP00000042469	ENSECAP00000006683	LAM_G_DOMAIN domain-containing protein.	Tumor protein p53 binding protein 1.	0.474
ENSECAP00000042469	VRK1	ENSECAP00000042469	ENSECAP00000031476	LAM_G_DOMAIN domain-containing protein.	VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily.	0.493
ENSECAP00000042469	VRK2	ENSECAP00000042469	ENSECAP00000018979	LAM_G_DOMAIN domain-containing protein.	VRK serine/threonine kinase 2.	0.493
MDC1	ATM	ENSECAP00000009219	ENSECAP00000025893	Mediator of DNA damage checkpoint 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.981
MDC1	ENSECAP00000042469	ENSECAP00000009219	ENSECAP00000042469	Mediator of DNA damage checkpoint 1.	LAM_G_DOMAIN domain-containing protein.	0.469
MDC1	PAXIP1	ENSECAP00000009219	ENSECAP00000015728	Mediator of DNA damage checkpoint 1.	PAX interacting protein 1.	0.402
MDC1	TP53BP1	ENSECAP00000009219	ENSECAP00000006683	Mediator of DNA damage checkpoint 1.	Tumor protein p53 binding protein 1.	0.957
PAXIP1	ATM	ENSECAP00000015728	ENSECAP00000025893	PAX interacting protein 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.823