ANAPC13 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ANAPC13

Anaphase promoting complex subunit 13. (74 aa)

Predicted Functional Partners:

CDC23

0.999

CDC16

0.999

CDC27

0.999

ANAPC5

0.998

ANAPC10

0.998

ANAPC2

0.997

CDC26

0.997

ANAPC4

0.996

ANAPC11

0.993

ANAPC7

0.992

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC10	ANAPC11	ENSECAP00000021879	ENSECAP00000000770	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	RING-type domain-containing protein.	0.998
ANAPC10	ANAPC13	ENSECAP00000021879	ENSECAP00000042866	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 13.	0.998
ANAPC10	ANAPC2	ENSECAP00000021879	ENSECAP00000016834	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.998
ANAPC10	ANAPC4	ENSECAP00000021879	ENSECAP00000015893	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.998
ANAPC10	ANAPC5	ENSECAP00000021879	ENSECAP00000021633	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 5.	0.998
ANAPC10	ANAPC7	ENSECAP00000021879	ENSECAP00000020444	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 7.	0.998
ANAPC10	CDC16	ENSECAP00000021879	ENSECAP00000018430	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 16.	0.998
ANAPC10	CDC23	ENSECAP00000021879	ENSECAP00000009755	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 23.	0.998
ANAPC10	CDC26	ENSECAP00000021879	ENSECAP00000039587	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 26.	0.998
ANAPC10	CDC27	ENSECAP00000021879	ENSECAP00000026054	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 27.	0.999
ANAPC11	ANAPC10	ENSECAP00000000770	ENSECAP00000021879	RING-type domain-containing protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.998
ANAPC11	ANAPC13	ENSECAP00000000770	ENSECAP00000042866	RING-type domain-containing protein.	Anaphase promoting complex subunit 13.	0.993
ANAPC11	ANAPC2	ENSECAP00000000770	ENSECAP00000016834	RING-type domain-containing protein.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.999
ANAPC11	ANAPC4	ENSECAP00000000770	ENSECAP00000015893	RING-type domain-containing protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.998
ANAPC11	ANAPC5	ENSECAP00000000770	ENSECAP00000021633	RING-type domain-containing protein.	Anaphase promoting complex subunit 5.	0.998
ANAPC11	ANAPC7	ENSECAP00000000770	ENSECAP00000020444	RING-type domain-containing protein.	Anaphase promoting complex subunit 7.	0.994
ANAPC11	CDC16	ENSECAP00000000770	ENSECAP00000018430	RING-type domain-containing protein.	Cell division cycle 16.	0.998
ANAPC11	CDC23	ENSECAP00000000770	ENSECAP00000009755	RING-type domain-containing protein.	Cell division cycle 23.	0.999
ANAPC11	CDC26	ENSECAP00000000770	ENSECAP00000039587	RING-type domain-containing protein.	Cell division cycle 26.	0.993
ANAPC11	CDC27	ENSECAP00000000770	ENSECAP00000026054	RING-type domain-containing protein.	Cell division cycle 27.	0.998

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Network Stats

number of nodes:

10

number of edges:

9

average node degree:

1.8

avg. local clustering coefficient:

0.9

expected number of edges:

9

PPI enrichment p-value:

0.549

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

7 of 17

1.89

3.48

3.32e-09

GO:0009099

Valine biosynthetic process

5 of 8

2.07

2.97

5.78e-07

GO:0009097

Isoleucine biosynthetic process

5 of 10

1.97

2.83

6.93e-07

GO:1901607

Alpha-amino acid biosynthetic process

7 of 59

1.35

1.79

8.69e-07

GO:1901605

Alpha-amino acid metabolic process

8 of 85

1.25

1.62

5.78e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003984

Acetolactate synthase activity

3 of 5

2.05

1.3

0.0032

GO:1990610

Acetolactate synthase regulator activity

2 of 2

2.27

0.85

0.0268

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:844

Valine, leucine and isoleucine biosynthesis, and Phosphopantetheine

9 of 20

1.93

4.8

1.32e-13

CL:845

Valine, leucine and isoleucine biosynthesis

8 of 15

2.0

4.76

1.48e-12

CL:846

Valine metabolic process

7 of 10

2.12

4.73

1.83e-11

CL:848

Valine metabolic process

3 of 5

2.05

1.83

0.00024

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

8 of 15

2.0

4.82

9.46e-13

map01210

2-Oxocarboxylic acid metabolism

7 of 22

1.78

3.39

7.67e-10

map00770

Pantothenate and CoA biosynthesis

5 of 19

1.7

2.35

1.49e-06

map00660

C5-Branched dibasic acid metabolism

4 of 10

1.88

2.35

7.07e-06

map01230

Biosynthesis of amino acids

8 of 94

1.2

1.6

1.27e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

3 of 5

2.05

1.49

0.0013

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 10

1.88

1.97

6.75e-05

KW-0432

Leucine biosynthesis

2 of 5

1.88

0.81

0.0287

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13710

ACT domain

2 of 2

2.27

0.72

0.0483

PF10369

Small subunit of acetolactate synthase

2 of 2

2.27

0.72

0.0483

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