SNCA protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SNCA

Alpha-synuclein; Belongs to the synuclein family. (255 aa)

Predicted Functional Partners:

PRKN

0.994

TH

0.990

HTT

0.961

SNCAIP

0.959

SLC18A2

0.945

HSPA5

0.929

SLC18A1

0.918

KLC1

0.915

KLC2

0.911

KLC4

0.910

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPA5	SNCA	ENSECAP00000021754	ENSECAP00000043218	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	Alpha-synuclein; Belongs to the synuclein family.	0.929
HTT	KLC1	ENSECAP00000007891	ENSECAP00000013087	Huntingtin.	Uncharacterized protein.	0.435
HTT	KLC2	ENSECAP00000007891	ENSECAP00000006375	Huntingtin.	Kinesin light chain 2.	0.617
HTT	KLC4	ENSECAP00000007891	ENSECAP00000030140	Huntingtin.	Kinesin light chain 4.	0.671
HTT	PRKN	ENSECAP00000007891	ENSECAP00000054587	Huntingtin.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.623
HTT	SNCA	ENSECAP00000007891	ENSECAP00000043218	Huntingtin.	Alpha-synuclein; Belongs to the synuclein family.	0.961
KLC1	HTT	ENSECAP00000013087	ENSECAP00000007891	Uncharacterized protein.	Huntingtin.	0.435
KLC1	KLC2	ENSECAP00000013087	ENSECAP00000006375	Uncharacterized protein.	Kinesin light chain 2.	0.969
KLC1	KLC4	ENSECAP00000013087	ENSECAP00000030140	Uncharacterized protein.	Kinesin light chain 4.	0.969
KLC1	SNCA	ENSECAP00000013087	ENSECAP00000043218	Uncharacterized protein.	Alpha-synuclein; Belongs to the synuclein family.	0.915
KLC2	HTT	ENSECAP00000006375	ENSECAP00000007891	Kinesin light chain 2.	Huntingtin.	0.617
KLC2	KLC1	ENSECAP00000006375	ENSECAP00000013087	Kinesin light chain 2.	Uncharacterized protein.	0.969
KLC2	KLC4	ENSECAP00000006375	ENSECAP00000030140	Kinesin light chain 2.	Kinesin light chain 4.	0.970
KLC2	SNCA	ENSECAP00000006375	ENSECAP00000043218	Kinesin light chain 2.	Alpha-synuclein; Belongs to the synuclein family.	0.911
KLC2	SNCAIP	ENSECAP00000006375	ENSECAP00000038107	Kinesin light chain 2.	Synuclein alpha interacting protein.	0.470
KLC4	HTT	ENSECAP00000030140	ENSECAP00000007891	Kinesin light chain 4.	Huntingtin.	0.671
KLC4	KLC1	ENSECAP00000030140	ENSECAP00000013087	Kinesin light chain 4.	Uncharacterized protein.	0.969
KLC4	KLC2	ENSECAP00000030140	ENSECAP00000006375	Kinesin light chain 4.	Kinesin light chain 2.	0.970
KLC4	SNCA	ENSECAP00000030140	ENSECAP00000043218	Kinesin light chain 4.	Alpha-synuclein; Belongs to the synuclein family.	0.910
PRKN	HTT	ENSECAP00000054587	ENSECAP00000007891	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Huntingtin.	0.623

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.887

expected number of edges:

22

PPI enrichment p-value:

0.233

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006261

DNA-templated DNA replication

8 of 100

2.23

5.71

1.94e-13

GO:0031570

DNA integrity checkpoint signaling

6 of 119

2.03

3.57

1.19e-08

GO:0006270

DNA replication initiation

4 of 22

2.59

3.49

2.55e-07

GO:0006275

Regulation of DNA replication

5 of 97

2.04

3.01

3.83e-07

GO:0090329

Regulation of DNA-templated DNA replication

4 of 44

2.29

2.94

1.65e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003688

DNA replication origin binding

3 of 13

2.69

2.15

0.00011

GO:0003697

Single-stranded DNA binding

3 of 86

1.87

1.09

0.0074

GO:0003677

DNA binding

8 of 2378

0.86

0.68

0.0018

GO:1901363

Heterocyclic compound binding

10 of 6288

0.53

0.38

0.0100

GO:0097159

Organic cyclic compound binding

10 of 6375

0.53

0.38

0.0100

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000228

Nuclear chromosome

6 of 153

1.92

3.18

4.76e-08

GO:0071162

CMG complex

3 of 11

2.77

2.94

3.79e-06

GO:0005657

Replication fork

4 of 48

2.25

2.87

2.13e-06

GO:0043596

Nuclear replication fork

3 of 22

2.47

2.5

1.96e-05

GO:0031298

Replication fork protection complex

2 of 3

3.16

2.04

0.00021

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25988259

(2015) An inactive geminin mutant that binds cdt1.

2 of 5

2.93

0.9

0.0240

PMID:32828016

(2020) Generation and characterization of keap1a- and keap1b-knockout zebrafish.

2 of 9

2.68

0.83

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3075

DNA replication preinitiation complex, and CDC6 association with the ORC:origin complex

7 of 29

2.71

7.21

8.55e-15

CL:2914

DNA-templated DNA replication, and HDR through Single Strand Annealing (SSA)

9 of 136

2.15

6.09

2.66e-15

CL:3079

DNA replication origin binding, and MCM domain

3 of 15

2.63

2.28

6.18e-05

CL:3081

Origin recognition complex, and AAA lid domain

2 of 8

2.73

1.17

0.0075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04110

Cell cycle

5 of 127

1.93

2.87

3.78e-07

ola03030

DNA replication

2 of 35

2.09

1.04

0.0108

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-176187

Activation of ATR in response to replication stress

5 of 38

2.45

4.27

4.00e-09

MAP-69481

G2/M Checkpoints

8 of 260

1.82

3.77

6.61e-11

MAP-68962

Activation of the pre-replicative complex

4 of 37

2.37

3.12

8.50e-07

MAP-69620

Cell Cycle Checkpoints

8 of 413

1.62

2.92

1.25e-09

MAP-5693532

DNA Double-Strand Break Repair

5 of 258

1.62

1.91

2.00e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005657

Replication fork

4 of 37

2.37

2.8

3.95e-06

GOCC:0031298

Replication fork protection complex

2 of 3

3.16

1.57

0.0015

GOCC:0042555

MCM complex

2 of 10

2.63

1.25

0.0052

GOCC:0005694

Chromosome

5 of 713

1.18

0.85

0.0052

GOCC:0032991

Protein-containing complex

9 of 5123

0.58

0.4

0.0118

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

2 of 43

2.0

0.73

0.0436

KW-0235

DNA replication

2 of 35

2.09

0.73

0.0436

KW-0539

Nucleus

5 of 1251

0.93

0.5

0.0436

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14551

MCM N-terminal domain

2 of 3

3.16

1.3

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041562

MCM, AAA-lid domain

2 of 9

2.68

0.78

0.0396

IPR033762

MCM OB domain

2 of 8

2.73

0.78

0.0396

IPR031327

Mini-chromosome maintenance protein

2 of 9

2.68

0.78

0.0396

IPR027925

MCM N-terminal domain

2 of 6

2.85

0.78

0.0396

IPR018525

Mini-chromosome maintenance, conserved site

2 of 6

2.85

0.78

0.0396

(more ...)

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