LOC111771846 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC111771846

Receptor-type tyrosine-protein phosphatase eta-like. (1211 aa)

Predicted Functional Partners:

MET

0.695

FLT3

0.673

HGF

0.614

PASK

0.539

PIANP

0.479

TCEA3

0.463

RPL13A

0.423

FLT3LG

0.413

KIDINS220

0.401

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FLT3	FLT3LG	ENSECAP00000052872	ENSECAP00000028171	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fms related tyrosine kinase 3 ligand.	0.951
FLT3	HGF	ENSECAP00000052872	ENSECAP00000009649	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.692
FLT3	LOC111771846	ENSECAP00000052872	ENSECAP00000044740	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Receptor-type tyrosine-protein phosphatase eta-like.	0.673
FLT3	RPL13A	ENSECAP00000052872	ENSECAP00000026299	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.730
FLT3LG	FLT3	ENSECAP00000028171	ENSECAP00000052872	Fms related tyrosine kinase 3 ligand.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.951
FLT3LG	LOC111771846	ENSECAP00000028171	ENSECAP00000044740	Fms related tyrosine kinase 3 ligand.	Receptor-type tyrosine-protein phosphatase eta-like.	0.413
HGF	FLT3	ENSECAP00000009649	ENSECAP00000052872	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.692
HGF	LOC111771846	ENSECAP00000009649	ENSECAP00000044740	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Receptor-type tyrosine-protein phosphatase eta-like.	0.614
HGF	MET	ENSECAP00000009649	ENSECAP00000008993	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.999
KIDINS220	LOC111771846	ENSECAP00000041776	ENSECAP00000044740	Kinase D interacting substrate 220.	Receptor-type tyrosine-protein phosphatase eta-like.	0.401
LOC111771846	FLT3	ENSECAP00000044740	ENSECAP00000052872	Receptor-type tyrosine-protein phosphatase eta-like.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.673
LOC111771846	FLT3LG	ENSECAP00000044740	ENSECAP00000028171	Receptor-type tyrosine-protein phosphatase eta-like.	Fms related tyrosine kinase 3 ligand.	0.413
LOC111771846	HGF	ENSECAP00000044740	ENSECAP00000009649	Receptor-type tyrosine-protein phosphatase eta-like.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.614
LOC111771846	KIDINS220	ENSECAP00000044740	ENSECAP00000041776	Receptor-type tyrosine-protein phosphatase eta-like.	Kinase D interacting substrate 220.	0.401
LOC111771846	MET	ENSECAP00000044740	ENSECAP00000008993	Receptor-type tyrosine-protein phosphatase eta-like.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.695
LOC111771846	PASK	ENSECAP00000044740	ENSECAP00000025510	Receptor-type tyrosine-protein phosphatase eta-like.	PAS domain containing serine/threonine kinase.	0.539
LOC111771846	PIANP	ENSECAP00000044740	ENSECAP00000013436	Receptor-type tyrosine-protein phosphatase eta-like.	PILR alpha associated neural protein.	0.479
LOC111771846	RPL13A	ENSECAP00000044740	ENSECAP00000026299	Receptor-type tyrosine-protein phosphatase eta-like.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.423
LOC111771846	TCEA3	ENSECAP00000044740	ENSECAP00000030744	Receptor-type tyrosine-protein phosphatase eta-like.	Transcription elongation factor A3.	0.463
MET	HGF	ENSECAP00000008993	ENSECAP00000009649	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.999