STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLATPlasminogen activator, tissue type. (615 aa)    
Predicted Functional Partners:
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 0.999
PLG
Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...]
   
 
0.993
ANXA2
Annexin.
   
 0.966
SERPINB2
Serpin family B member 10; Belongs to the serpin family.
    
 0.945
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.933
S100A10
S100 calcium binding protein A10; Belongs to the S-100 family.
   
 0.914
SERPINF2
Serpin family F member 2; Belongs to the serpin family.
   
 0.908
VTN
Vitronectin.
   
 0.800
PDGFC
Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
    
 0.782
CD4
CD4 molecule.
    
 0.761
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.