CCL4 protein (Equus caballus) - STRING interaction network

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Score

CCL4

SCY domain-containing protein. (97 aa)

Predicted Functional Partners:

CCL2

0.992

CXCL13

0.985

CCR1

0.972

CCL5

0.970

CCL8

0.965

CCR5

0.963

CCR2

0.959

CCR3

0.947

CCL3

0.944

CXCR4

0.940

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL3	ENSECAP00000021376	ENSECAP00000047808	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.821
CCL2	CCL4	ENSECAP00000021376	ENSECAP00000046856	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.992
CCL2	CCL5	ENSECAP00000021376	ENSECAP00000022430	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.984
CCL2	CCL8	ENSECAP00000021376	ENSECAP00000021367	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.990
CCL2	CCR1	ENSECAP00000021376	ENSECAP00000001353	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.963
CCL2	CCR2	ENSECAP00000021376	ENSECAP00000000857	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL2	CCR3	ENSECAP00000021376	ENSECAP00000001001	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.983
CCL2	CCR5	ENSECAP00000021376	ENSECAP00000000806	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.968
CCL2	CXCL13	ENSECAP00000021376	ENSECAP00000009631	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.982
CCL2	CXCR4	ENSECAP00000021376	ENSECAP00000002602	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.953
CCL3	CCL2	ENSECAP00000047808	ENSECAP00000021376	SCY domain-containing protein.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.821
CCL3	CCL4	ENSECAP00000047808	ENSECAP00000046856	SCY domain-containing protein.	SCY domain-containing protein.	0.944
CCL3	CCL5	ENSECAP00000047808	ENSECAP00000022430	SCY domain-containing protein.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.710
CCL3	CCL8	ENSECAP00000047808	ENSECAP00000021367	SCY domain-containing protein.	SCY domain-containing protein.	0.409
CCL3	CCR1	ENSECAP00000047808	ENSECAP00000001353	SCY domain-containing protein.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.979
CCL3	CCR2	ENSECAP00000047808	ENSECAP00000000857	SCY domain-containing protein.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.848
CCL3	CCR3	ENSECAP00000047808	ENSECAP00000001001	SCY domain-containing protein.	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.900
CCL3	CCR5	ENSECAP00000047808	ENSECAP00000000806	SCY domain-containing protein.	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.994
CCL3	CXCL13	ENSECAP00000047808	ENSECAP00000009631	SCY domain-containing protein.	C-X-C motif chemokine.	0.916
CCL3	CXCR4	ENSECAP00000047808	ENSECAP00000002602	SCY domain-containing protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.843