STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. (393 aa)    
Predicted Functional Partners:
MAOA
Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).
   
 
 0.991
MAOB
Amine oxidase.
     
 0.990
CYP1B1
Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.
   
 
 0.979
CYP1A1
Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.970
DBH
Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family.
     
 0.969
DDC
Dopa decarboxylase.
   
 
 0.966
ALDH3B1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 
 0.951
ALDH3A1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 
 0.949
LOC100146977
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
    
 0.947
F6WNE2_HORSE
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
    
 0.947
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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