node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH3A1 | ALDH3B1 | ENSECAP00000008456 | ENSECAP00000027431 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.905 |
ALDH3A1 | COMT | ENSECAP00000008456 | ENSECAP00000047104 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.949 |
ALDH3A1 | CYP1A1 | ENSECAP00000008456 | ENSECAP00000012229 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.532 |
ALDH3A1 | CYP1B1 | ENSECAP00000008456 | ENSECAP00000017028 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.519 |
ALDH3A1 | MAOA | ENSECAP00000008456 | ENSECAP00000043359 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.973 |
ALDH3A1 | MAOB | ENSECAP00000008456 | ENSECAP00000001087 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Amine oxidase. | 0.974 |
ALDH3B1 | ALDH3A1 | ENSECAP00000027431 | ENSECAP00000008456 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.905 |
ALDH3B1 | COMT | ENSECAP00000027431 | ENSECAP00000047104 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.951 |
ALDH3B1 | CYP1B1 | ENSECAP00000027431 | ENSECAP00000017028 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.435 |
ALDH3B1 | MAOA | ENSECAP00000027431 | ENSECAP00000043359 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.974 |
ALDH3B1 | MAOB | ENSECAP00000027431 | ENSECAP00000001087 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Amine oxidase. | 0.974 |
COMT | ALDH3A1 | ENSECAP00000047104 | ENSECAP00000008456 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.949 |
COMT | ALDH3B1 | ENSECAP00000047104 | ENSECAP00000027431 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.951 |
COMT | CYP1A1 | ENSECAP00000047104 | ENSECAP00000012229 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.970 |
COMT | CYP1B1 | ENSECAP00000047104 | ENSECAP00000017028 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.979 |
COMT | DBH | ENSECAP00000047104 | ENSECAP00000017330 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.969 |
COMT | DDC | ENSECAP00000047104 | ENSECAP00000007803 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Dopa decarboxylase. | 0.966 |
COMT | F6WNE2_HORSE | ENSECAP00000047104 | ENSECAP00000014848 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.947 |
COMT | LOC100146977 | ENSECAP00000047104 | ENSECAP00000006973 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.947 |
COMT | MAOA | ENSECAP00000047104 | ENSECAP00000043359 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.991 |