STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADNPActivity dependent neuroprotector homeobox. (1103 aa)    
Predicted Functional Partners:
CHD4
Chromodomain helicase DNA binding protein 4.
   
 
 0.908
BPTF
Bromodomain PHD finger transcription factor.
   
  
 0.799
TMEM125
Transmembrane protein 125.
      
 0.771
MPHOSPH8
M-phase phosphoprotein 8.
   
 
 0.746
DNAJC16
DnaJ heat shock protein family (Hsp40) member C16.
      
 0.741
ACBD5
Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters.
      
 0.735
PJA2
Praja ring finger ubiquitin ligase 2.
   
  
 0.713
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 
 0.711
CREBRF
CREB3 regulatory factor.
   
 
 0.694
ZNF280C
Zinc finger protein 280C.
   
 
 0.693
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.