STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)    
Predicted Functional Partners:
EQMHCC1
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.984
LOC100054114
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.980
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.975
MHCB3
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.973
LOC100050473
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.972
LOC100059994
Uncharacterized protein; Belongs to the MHC class I family.
   
 0.972
WRN
WRN RecQ like helicase.
   
 0.956
RPA3
Replication protein A3.
   
 0.954
ENSECAP00000025114
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.941
LOC100056182
Uncharacterized protein; Belongs to the MHC class I family.
   
 0.937
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.