STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCG2Secretogranin II. (704 aa)    
Predicted Functional Partners:
CHGB
Chromogranin B.
   
  
 0.932
NPFF
Neuropeptide FF-amide peptide precursor.
      
 0.747
CHGA
p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
   
 
 0.727
CHGA-2
Chromogranin A.
   
 
 0.679
PCSK1N
Proprotein convertase subtilisin/kexin type 1 inhibitor.
   
  
 0.664
PTPN5
Protein tyrosine phosphatase non-receptor type 5.
   
  
 0.647
VGF
VGF nerve growth factor inducible.
   
  
 0.629
CPE
Carboxypeptidase E.
   
  
 0.607
NPY
Neuropeptide Y.
      
 0.595
RLN3
Relaxin 3.
  
   
 0.585
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.