IL18BP protein (Equus caballus) - STRING interaction network

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Score

IL18BP

Interleukin 18 binding protein. (259 aa)

Predicted Functional Partners:

IL37

0.953

IL18

0.927

IGFLR1

0.698

ENSECAP00000030557

0.617

IL1RN

0.525

IL18R1

0.503

IL1R2

0.489

IL27RA

0.473

IRAK1BP1

0.428

TBP

0.427

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECAP00000030557	IL18	ENSECAP00000030557	ENSECAP00000040862	Uncharacterized protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.916
ENSECAP00000030557	IL18BP	ENSECAP00000030557	ENSECAP00000049055	Uncharacterized protein.	Interleukin 18 binding protein.	0.617
ENSECAP00000030557	IL18R1	ENSECAP00000030557	ENSECAP00000034287	Uncharacterized protein.	Interleukin 18 receptor 1.	0.975
ENSECAP00000030557	IL37	ENSECAP00000030557	ENSECAP00000048404	Uncharacterized protein.	Interleukin-1.	0.900
IGFLR1	IL18BP	ENSECAP00000015377	ENSECAP00000049055	IGF like family receptor 1.	Interleukin 18 binding protein.	0.698
IL18	ENSECAP00000030557	ENSECAP00000040862	ENSECAP00000030557	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Uncharacterized protein.	0.916
IL18	IL18BP	ENSECAP00000040862	ENSECAP00000049055	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 binding protein.	0.927
IL18	IL18R1	ENSECAP00000040862	ENSECAP00000034287	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor 1.	0.996
IL18	IL1R2	ENSECAP00000040862	ENSECAP00000046450	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 1 receptor type 2.	0.408
IL18	IL1RN	ENSECAP00000040862	ENSECAP00000052943	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family.	0.628
IL18	IL37	ENSECAP00000040862	ENSECAP00000048404	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-1.	0.964
IL18BP	ENSECAP00000030557	ENSECAP00000049055	ENSECAP00000030557	Interleukin 18 binding protein.	Uncharacterized protein.	0.617
IL18BP	IGFLR1	ENSECAP00000049055	ENSECAP00000015377	Interleukin 18 binding protein.	IGF like family receptor 1.	0.698
IL18BP	IL18	ENSECAP00000049055	ENSECAP00000040862	Interleukin 18 binding protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.927
IL18BP	IL18R1	ENSECAP00000049055	ENSECAP00000034287	Interleukin 18 binding protein.	Interleukin 18 receptor 1.	0.503
IL18BP	IL1R2	ENSECAP00000049055	ENSECAP00000046450	Interleukin 18 binding protein.	Interleukin 1 receptor type 2.	0.489
IL18BP	IL1RN	ENSECAP00000049055	ENSECAP00000052943	Interleukin 18 binding protein.	Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family.	0.525
IL18BP	IL27RA	ENSECAP00000049055	ENSECAP00000009925	Interleukin 18 binding protein.	Interleukin 27 receptor subunit alpha.	0.473
IL18BP	IL37	ENSECAP00000049055	ENSECAP00000048404	Interleukin 18 binding protein.	Interleukin-1.	0.953
IL18BP	IRAK1BP1	ENSECAP00000049055	ENSECAP00000007158	Interleukin 18 binding protein.	Interleukin 1 receptor associated kinase 1 binding protein 1.	0.428