EFCAB2 protein (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

EFCAB2

EF-hand domain-containing protein. (170 aa)

Predicted Functional Partners:

TAX1BP1

0.778

RNF11

0.675

EFCAB11

0.673

TTLL7

0.664

CASK

0.659

CHI3L1

0.611

MAST2

0.555

WDR90

0.521

HRC

0.511

ITPRID1

0.497

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASK	EFCAB11	ENSECAP00000012271	ENSECAP00000016233	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	EF-hand calcium binding domain 11.	0.659
CASK	EFCAB2	ENSECAP00000012271	ENSECAP00000049634	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	EF-hand domain-containing protein.	0.659
CHI3L1	EFCAB2	ENSECAP00000039440	ENSECAP00000049634	Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family.	EF-hand domain-containing protein.	0.611
EFCAB11	CASK	ENSECAP00000016233	ENSECAP00000012271	EF-hand calcium binding domain 11.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.659
EFCAB11	EFCAB2	ENSECAP00000016233	ENSECAP00000049634	EF-hand calcium binding domain 11.	EF-hand domain-containing protein.	0.673
EFCAB11	MAST2	ENSECAP00000016233	ENSECAP00000007571	EF-hand calcium binding domain 11.	Microtubule associated serine/threonine kinase 2.	0.484
EFCAB11	TTLL7	ENSECAP00000016233	ENSECAP00000025138	EF-hand calcium binding domain 11.	Tubulin tyrosine ligase like 7.	0.489
EFCAB11	WDR90	ENSECAP00000016233	ENSECAP00000043683	EF-hand calcium binding domain 11.	WD repeat domain 90.	0.521
EFCAB2	CASK	ENSECAP00000049634	ENSECAP00000012271	EF-hand domain-containing protein.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.659
EFCAB2	CHI3L1	ENSECAP00000049634	ENSECAP00000039440	EF-hand domain-containing protein.	Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family.	0.611
EFCAB2	EFCAB11	ENSECAP00000049634	ENSECAP00000016233	EF-hand domain-containing protein.	EF-hand calcium binding domain 11.	0.673
EFCAB2	HRC	ENSECAP00000049634	ENSECAP00000053787	EF-hand domain-containing protein.	Histidine rich calcium binding protein.	0.511
EFCAB2	ITPRID1	ENSECAP00000049634	ENSECAP00000018691	EF-hand domain-containing protein.	ITPR interacting domain containing 1.	0.497
EFCAB2	MAST2	ENSECAP00000049634	ENSECAP00000007571	EF-hand domain-containing protein.	Microtubule associated serine/threonine kinase 2.	0.555
EFCAB2	RNF11	ENSECAP00000049634	ENSECAP00000032627	EF-hand domain-containing protein.	Ring finger protein 11.	0.675
EFCAB2	TAX1BP1	ENSECAP00000049634	ENSECAP00000002963	EF-hand domain-containing protein.	Tax1 binding protein 1.	0.778
EFCAB2	TTLL7	ENSECAP00000049634	ENSECAP00000025138	EF-hand domain-containing protein.	Tubulin tyrosine ligase like 7.	0.664
EFCAB2	WDR90	ENSECAP00000049634	ENSECAP00000043683	EF-hand domain-containing protein.	WD repeat domain 90.	0.521
HRC	EFCAB2	ENSECAP00000053787	ENSECAP00000049634	Histidine rich calcium binding protein.	EF-hand domain-containing protein.	0.511
ITPRID1	EFCAB2	ENSECAP00000018691	ENSECAP00000049634	ITPR interacting domain containing 1.	EF-hand domain-containing protein.	0.497

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

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