node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | ENSECAP00000051178 | ENSECAP00000013428 | ENSECAP00000051178 | Angiotensinogen; Belongs to the serpin family. | Peptidase S1 domain-containing protein. | 0.686 |
AGT | MMP9 | ENSECAP00000013428 | ENSECAP00000011232 | Angiotensinogen; Belongs to the serpin family. | Matrix metallopeptidase 9. | 0.553 |
BID | CASP1 | ENSECAP00000004764 | ENSECAP00000021890 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | 0.944 |
BID | CASP4 | ENSECAP00000004764 | ENSECAP00000010831 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.573 |
BID | ENSECAP00000051178 | ENSECAP00000004764 | ENSECAP00000051178 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Peptidase S1 domain-containing protein. | 0.433 |
BID | LOC100069322 | ENSECAP00000004764 | ENSECAP00000027514 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.464 |
CASP1 | BID | ENSECAP00000021890 | ENSECAP00000004764 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.944 |
CASP1 | CASP4 | ENSECAP00000021890 | ENSECAP00000010831 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.581 |
CASP1 | ENSECAP00000051178 | ENSECAP00000021890 | ENSECAP00000051178 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Peptidase S1 domain-containing protein. | 0.440 |
CASP1 | LOC100069322 | ENSECAP00000021890 | ENSECAP00000027514 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.552 |
CASP4 | BID | ENSECAP00000010831 | ENSECAP00000004764 | Uncharacterized protein; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.573 |
CASP4 | CASP1 | ENSECAP00000010831 | ENSECAP00000021890 | Uncharacterized protein; Belongs to the peptidase C14A family. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | 0.581 |
CASP4 | ENSECAP00000051178 | ENSECAP00000010831 | ENSECAP00000051178 | Uncharacterized protein; Belongs to the peptidase C14A family. | Peptidase S1 domain-containing protein. | 0.440 |
CASP4 | LOC100069322 | ENSECAP00000010831 | ENSECAP00000027514 | Uncharacterized protein; Belongs to the peptidase C14A family. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.552 |
ELANE | ENSECAP00000051178 | ENSECAP00000028055 | ENSECAP00000051178 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein. | 0.653 |
ELANE | F6Y785_HORSE | ENSECAP00000028055 | ENSECAP00000019216 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.499 |
ELANE | LOC100146723 | ENSECAP00000028055 | ENSECAP00000013832 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.510 |
ELANE | MET | ENSECAP00000028055 | ENSECAP00000008993 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.496 |
ELANE | MMP9 | ENSECAP00000028055 | ENSECAP00000011232 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Matrix metallopeptidase 9. | 0.692 |
ENSECAP00000051178 | AGT | ENSECAP00000051178 | ENSECAP00000013428 | Peptidase S1 domain-containing protein. | Angiotensinogen; Belongs to the serpin family. | 0.686 |