STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GCGGlucagon. (232 aa)    
Predicted Functional Partners:
GCGR
Glucagon receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.999
GLP1R
Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.998
GLP2R
Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.992
GPR119
G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.
     
 0.981
GIPR
Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.978
INS
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.956
GHRL
Ghrelin and obestatin prepropeptide.
   
 
 0.945
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]
     
 0.945
SST
Somatostatin.
   
  
 0.935
VIPR2
Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family.
    
 0.932
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.