STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)    
Predicted Functional Partners:
CD22
CD22 molecule.
   
 0.991
SYK
Tyrosine-protein kinase.
   
 0.979
JAK2
Tyrosine-protein kinase.
   
 0.971
JAK1
Tyrosine-protein kinase.
   
 0.966
JAK3
Tyrosine-protein kinase.
   
 0.964
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.959
CD247
CD247 molecule.
   
 0.957
VAV1
Vav guanine nucleotide exchange factor 1.
   
0.954
LCP2
Lymphocyte cytosolic protein 2.
   
 0.954
TYK2
Tyrosine-protein kinase.
   
 0.952
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.