STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHANK1SH3 and multiple ankyrin repeat domains 1. (2170 aa)    
Predicted Functional Partners:
SHANK3
SH3 and multiple ankyrin repeat domains 3.
  
 
0.973
SHANK2
SH3 and multiple ankyrin repeat domains 2.
    
0.948
DLGAP1
DLG associated protein 1.
   
 0.894
DLGAP2
DLG associated protein 2.
   
 0.832
DLGAP4
DLG associated protein 4.
    
 0.819
SYT3
Synaptotagmin 3.
   
 
 0.791
EMC10
ER membrane protein complex subunit 10.
      
 0.787
NLGN3
Neuroligin 3.
   
 0.762
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
   
 0.736
LZTS2
Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin.
   
 0.728
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.