SIL1 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SIL1

SIL1 nucleotide exchange factor. (472 aa)

Predicted Functional Partners:

HSPA5

0.967

HYOU1

0.959

RPL5

0.924

ENSECAP00000033963

0.904

RPL23

0.902

TUFM

0.898

MRPL17

0.897

MED1

0.893

MRPS9

0.893

RPS11

0.891

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECAP00000033963	MED1	ENSECAP00000033963	ENSECAP00000007560	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.994
ENSECAP00000033963	RPL23	ENSECAP00000033963	ENSECAP00000038347	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.997
ENSECAP00000033963	RPL5	ENSECAP00000033963	ENSECAP00000018699	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein L5.	0.997
ENSECAP00000033963	RPS11	ENSECAP00000033963	ENSECAP00000000228	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.999
ENSECAP00000033963	SIL1	ENSECAP00000033963	ENSECAP00000054326	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	SIL1 nucleotide exchange factor.	0.904
HSPA5	HYOU1	ENSECAP00000021754	ENSECAP00000011454	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	Hypoxia up-regulated 1.	0.990
HSPA5	RPL5	ENSECAP00000021754	ENSECAP00000018699	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	Ribosomal protein L5.	0.408
HSPA5	SIL1	ENSECAP00000021754	ENSECAP00000054326	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	SIL1 nucleotide exchange factor.	0.967
HYOU1	HSPA5	ENSECAP00000011454	ENSECAP00000021754	Hypoxia up-regulated 1.	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	0.990
HYOU1	RPL5	ENSECAP00000011454	ENSECAP00000018699	Hypoxia up-regulated 1.	Ribosomal protein L5.	0.527
HYOU1	SIL1	ENSECAP00000011454	ENSECAP00000054326	Hypoxia up-regulated 1.	SIL1 nucleotide exchange factor.	0.959
MED1	ENSECAP00000033963	ENSECAP00000007560	ENSECAP00000033963	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.994
MED1	MRPL17	ENSECAP00000007560	ENSECAP00000008082	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.976
MED1	MRPS9	ENSECAP00000007560	ENSECAP00000009224	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.976
MED1	RPL23	ENSECAP00000007560	ENSECAP00000038347	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.982
MED1	RPL5	ENSECAP00000007560	ENSECAP00000018699	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Ribosomal protein L5.	0.987
MED1	RPS11	ENSECAP00000007560	ENSECAP00000000228	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.976
MED1	SIL1	ENSECAP00000007560	ENSECAP00000054326	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	SIL1 nucleotide exchange factor.	0.893
MED1	TUFM	ENSECAP00000007560	ENSECAP00000053013	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.976
MRPL17	MED1	ENSECAP00000008082	ENSECAP00000007560	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.976