STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHANK3SH3 and multiple ankyrin repeat domains 3. (1807 aa)    
Predicted Functional Partners:
SHANK1
SH3 and multiple ankyrin repeat domains 1.
  
 
0.973
SHANK2
SH3 and multiple ankyrin repeat domains 2.
   
0.957
DLGAP2
DLG associated protein 2.
   
 0.927
NLGN3
Neuroligin 3.
   
 0.869
MECP2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
      
 0.847
NRXN1
Neurexin 1.
   
 0.843
HOMER1
Homer scaffold protein 1.
    
 0.822
DLGAP1
DLG associated protein 1.
   
 0.818
DLGAP4
DLG associated protein 4.
   
 0.815
FMR1
Fragile X mental retardation 1.
    
 0.799
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.