STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOX2TOX high mobility group box family member 2. (552 aa)    
Predicted Functional Partners:
ARHGEF3
Rho guanine nucleotide exchange factor 3.
    
 
 0.747
DAPP1
Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.
   
 
 0.711
NDFIP2
Nedd4 family interacting protein 2.
      
 0.651
PDE4A
Phosphodiesterase.
   
  
 0.639
MINDY4
MINDY lysine 48 deubiquitinase 4.
   
  
 0.638
SH2B3
SH2B adaptor protein 3.
   
  
 0.636
USP22
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
      
 0.629
ASB2
Ankyrin repeat and SOCS box containing 2.
    
 0.563
ACTR8
Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.
    
 0.521
ZNF516
Zinc finger protein 516.
    
 0.510
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.