STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A2V1DBX4SET domain-containing protein. (449 aa)    
Predicted Functional Partners:
A0A2V1DC46
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.701
A0A2V1D1E6
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
    
 0.691
A0A2V1DX86
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
    
 0.664
A0A2V1E496
SET domain-containing protein.
    
 0.658
A0A2V1E238
WD40 repeat-like protein.
    
 0.636
A0A2V1ECY8
WD40 repeat-like protein.
    
 0.623
A0A2V1E3P5
SPRY domain-containing protein.
    
 0.622
A0A2V1E0J6
VEFS-Box domain-containing protein.
    
 0.621
A0A2V1DQC4
WD40 repeat-like protein.
    
 0.614
A0A2V1E9W2
Histone H2B; Belongs to the histone H2B family.
    
 0.580
Your Current Organism:
Periconia macrospinosa
NCBI taxonomy Id: 97972
Other names: P. macrospinosa
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.