node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OAI10761.1 | dcd | A1359_16020 | A1359_05515 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.857 |
OAI10761.1 | dut | A1359_16020 | A1359_10535 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.953 |
OAI10761.1 | mazG | A1359_16020 | A1359_15080 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.504 |
OAI10761.1 | ndk | A1359_16020 | A1359_12545 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.936 |
OAI10761.1 | pyrG | A1359_16020 | A1359_15455 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.859 |
OAI10761.1 | thyA | A1359_16020 | A1359_09650 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.862 |
OAI10761.1 | tmk | A1359_16020 | A1359_18405 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.903 |
OAI17909.1 | dcd | A1359_05510 | A1359_05515 | Glycosyl hydrolase family 15; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.646 |
OAI17909.1 | glk | A1359_05510 | A1359_05505 | Glycosyl hydrolase family 15; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. | 0.813 |
OAI20622.1 | dcd | A1359_20670 | A1359_05515 | NAD(P)-dependent oxidoreductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.724 |
dcd | OAI10761.1 | A1359_05515 | A1359_16020 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.857 |
dcd | OAI17909.1 | A1359_05515 | A1359_05510 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Glycosyl hydrolase family 15; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.646 |
dcd | OAI20622.1 | A1359_05515 | A1359_20670 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | NAD(P)-dependent oxidoreductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. | 0.724 |
dcd | dut | A1359_05515 | A1359_10535 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.922 |
dcd | glk | A1359_05515 | A1359_05505 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. | 0.637 |
dcd | mazG | A1359_05515 | A1359_15080 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.908 |
dcd | ndk | A1359_05515 | A1359_12545 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
dcd | pyrG | A1359_05515 | A1359_15455 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.917 |
dcd | thyA | A1359_05515 | A1359_09650 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.630 |
dcd | tmk | A1359_05515 | A1359_18405 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.659 |