STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpPATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (199 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 0.999
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
   
 
 0.955
AEP11297.1
ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family.
   
 
 0.895
AEP11910.1
ATP-dependent Clp protease ATP-binding subunit ClpB; C-terminal, D2-small domain, of ClpB protein, ATPase family associated with various cellular activities (AAA).
   
 
 0.895
AEP12650.1
ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family.
   
 
 0.895
AEP13678.1
ATP-dependent Clp protease ATP-binding subunit clpA; Belongs to the ClpA/ClpB family.
   
 
 0.895
hrcA
Heat shock gene repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.864
hslV
ATP-dependent protease HslVU (ClpYQ), peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
  
 
 0.813
clpS
Uncharacterized conserved protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
   
 
 0.756
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
  
 0.743
Your Current Organism:
Chloracidobacterium thermophilum
NCBI taxonomy Id: 981222
Other names: C. thermophilum B, Candidatus Chloracidobacterium thermophilum B, Chloracidobacterium thermophilum B, Chloracidobacterium thermophilum str. B, Chloracidobacterium thermophilum strain B
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