AEP11993.1 protein (Chloracidobacterium thermophilum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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Score

AEP11993.1

Signal transduction histidine kinase. (397 aa)

Predicted Functional Partners:

AEP12190.1

0.991

AEP13601.1

0.991

AEP13730.1

0.991

AEP12890.1

0.989

AEP11569.1

0.985

AEP13551.1

0.984

AEP13819.1

0.981

AEP11032.1

0.956

AEP11451.1

0.950

AEP11315.1

0.932

Your Current Organism:

Chloracidobacterium thermophilum

NCBI taxonomy Id: 981222
Other names: C. thermophilum B, Candidatus Chloracidobacterium thermophilum B, Chloracidobacterium thermophilum B, Chloracidobacterium thermophilum str. B, Chloracidobacterium thermophilum strain B

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEP11032.1	AEP11315.1	Cabther_A0265	Cabther_A0557	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	0.491
AEP11032.1	AEP11451.1	Cabther_A0265	Cabther_A0694	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.938
AEP11032.1	AEP11569.1	Cabther_A0265	Cabther_A0812	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.993
AEP11032.1	AEP11993.1	Cabther_A0265	Cabther_A1239	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.956
AEP11032.1	AEP12190.1	Cabther_A0265	Cabther_A1439	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.991
AEP11032.1	AEP12890.1	Cabther_A0265	Cabther_A2152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.993
AEP11032.1	AEP13551.1	Cabther_A0265	Cabther_B0553	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.986
AEP11032.1	AEP13601.1	Cabther_A0265	Cabther_B0603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase regulating C4-dicarboxylate transport system.	0.983
AEP11032.1	AEP13730.1	Cabther_A0265	Cabther_B0733	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.994
AEP11032.1	AEP13819.1	Cabther_A0265	Cabther_B0822	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.986
AEP11315.1	AEP11032.1	Cabther_A0557	Cabther_A0265	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	0.491
AEP11315.1	AEP11451.1	Cabther_A0557	Cabther_A0694	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.825
AEP11315.1	AEP11569.1	Cabther_A0557	Cabther_A0812	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.980
AEP11315.1	AEP11993.1	Cabther_A0557	Cabther_A1239	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.932
AEP11315.1	AEP12190.1	Cabther_A0557	Cabther_A1439	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.400
AEP11315.1	AEP12890.1	Cabther_A0557	Cabther_A2152	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	PAS domain S-box.	0.775
AEP11315.1	AEP13551.1	Cabther_A0557	Cabther_B0553	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.500
AEP11315.1	AEP13601.1	Cabther_A0557	Cabther_B0603	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase regulating C4-dicarboxylate transport system.	0.779
AEP11315.1	AEP13730.1	Cabther_A0557	Cabther_B0733	Two-component system, cell cycle response regulator DivK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	Signal transduction histidine kinase.	0.911
AEP11451.1	AEP11032.1	Cabther_A0694	Cabther_A0265	PAS domain S-box.	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein.	0.938

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

9 of 81

1.84

4.3

6.87e-13

GO:0006091

Generation of precursor metabolites and energy

10 of 193

1.51

2.94

3.72e-12

GO:0055085

Transmembrane transport

8 of 1060

0.67

0.45

0.0148

GO:0044237

Cellular metabolic process

11 of 2364

0.46

0.36

0.0047

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048038

Quinone binding

8 of 18

2.44

6.97

2.09e-15

GO:0050136

NADH dehydrogenase (quinone) activity

8 of 21

2.37

6.75

2.86e-15

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 27

2.21

5.29

1.74e-12

GO:0008137

NADH dehydrogenase (ubiquinone) activity

6 of 15

2.39

5.24

1.86e-11

GO:0009055

Electron transfer activity

8 of 64

1.89

4.37

1.96e-12

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

2 of 13

1.98

1.06

0.0095

GO:0005886

Plasma membrane

8 of 1235

0.6

0.43

0.0090

GO:0016020

Membrane

11 of 2142

0.5

0.42

0.00047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1473

NADH dehydrogenase activity, and Thioredoxin-like [2Fe-2S] ferredoxin

8 of 24

2.31

6.61

2.51e-15

CL:1418

Oxidative phosphorylation, and Cytochrome c

10 of 52

2.08

6.54

5.00e-18

CL:1477

Quinone, and Proton-conducting membrane transporter

7 of 14

2.49

6.54

4.27e-14

CL:1415

Oxidative phosphorylation, and Cytochrome c

11 of 70

1.99

6.32

5.00e-19

CL:1425

Mixed, incl. Respiratory chain, and Peptidase M16 inactive domain

2 of 14

1.95

0.75

0.0387

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

10 of 70

1.95

5.69

4.26e-17

map01100

Metabolic pathways

11 of 2505

0.43

0.36

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030964

NADH dehydrogenase complex

5 of 13

2.38

4.13

5.69e-09

GOCC:0070469

Respirasome

6 of 35

2.03

3.68

5.20e-09

GOCC:0045271

Respiratory chain complex I

4 of 10

2.39

3.28

4.32e-07

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 5

2.39

1.43

0.0022

GOCC:0005743

Mitochondrial inner membrane

2 of 17

1.86

0.97

0.0129

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0874

Quinone

7 of 11

2.6

6.87

1.91e-14

KW-0830

Ubiquinone

7 of 25

2.24

5.46

1.00e-12

KW-1278

Translocase

6 of 31

2.08

4.15

4.69e-10

KW-0520

NAD

7 of 68

1.8

3.54

3.86e-10

KW-0004

4Fe-4S

4 of 38

1.81

2.15

1.68e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

2.79

1.06

0.0119

PF00037

4Fe-4S binding domain

2 of 4

2.49

1.0

0.0149

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