GRN protein (Procavia capensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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Co-expression

Experiments

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[Homology]

Score

GRN

Granulin precursor. (594 aa)

Predicted Functional Partners:

SORT1

0.983

CTSB

0.909

GLRX3

0.873

CD68

0.865

PSAP

0.856

CDK9

0.778

CTSZ

0.769

DNAJC10

0.750

LAMP1

0.743

BAP1

0.727

Your Current Organism:

Procavia capensis

NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAP1	GRN	ENSPCAP00000010839	ENSPCAP00000001230	BRCA1 associated protein 1.	Granulin precursor.	0.727
CD68	CTSB	ENSPCAP00000012129	ENSPCAP00000015490	CD68 molecule.	Cathepsin B.	0.504
CD68	CTSZ	ENSPCAP00000012129	ENSPCAP00000008681	CD68 molecule.	Cathepsin Z.	0.770
CD68	GRN	ENSPCAP00000012129	ENSPCAP00000001230	CD68 molecule.	Granulin precursor.	0.865
CD68	LAMP1	ENSPCAP00000012129	ENSPCAP00000010307	CD68 molecule.	Lysosomal associated membrane protein 1.	0.897
CD68	PSAP	ENSPCAP00000012129	ENSPCAP00000012169	CD68 molecule.	Prosaposin.	0.451
CDK9	GRN	ENSPCAP00000008289	ENSPCAP00000001230	Cyclin dependent kinase 9.	Granulin precursor.	0.778
CTSB	CD68	ENSPCAP00000015490	ENSPCAP00000012129	Cathepsin B.	CD68 molecule.	0.504
CTSB	CTSZ	ENSPCAP00000015490	ENSPCAP00000008681	Cathepsin B.	Cathepsin Z.	0.935
CTSB	GRN	ENSPCAP00000015490	ENSPCAP00000001230	Cathepsin B.	Granulin precursor.	0.909
CTSB	LAMP1	ENSPCAP00000015490	ENSPCAP00000010307	Cathepsin B.	Lysosomal associated membrane protein 1.	0.934
CTSB	PSAP	ENSPCAP00000015490	ENSPCAP00000012169	Cathepsin B.	Prosaposin.	0.780
CTSZ	CD68	ENSPCAP00000008681	ENSPCAP00000012129	Cathepsin Z.	CD68 molecule.	0.770
CTSZ	CTSB	ENSPCAP00000008681	ENSPCAP00000015490	Cathepsin Z.	Cathepsin B.	0.935
CTSZ	GRN	ENSPCAP00000008681	ENSPCAP00000001230	Cathepsin Z.	Granulin precursor.	0.769
CTSZ	LAMP1	ENSPCAP00000008681	ENSPCAP00000010307	Cathepsin Z.	Lysosomal associated membrane protein 1.	0.724
CTSZ	PSAP	ENSPCAP00000008681	ENSPCAP00000012169	Cathepsin Z.	Prosaposin.	0.576
DNAJC10	GRN	ENSPCAP00000011014	ENSPCAP00000001230	DnaJ heat shock protein family (Hsp40) member C10.	Granulin precursor.	0.750
GLRX3	GRN	ENSPCAP00000011178	ENSPCAP00000001230	Glutaredoxin 3.	Granulin precursor.	0.873
GRN	BAP1	ENSPCAP00000001230	ENSPCAP00000010839	Granulin precursor.	BRCA1 associated protein 1.	0.727