Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SH2B2SH2B adaptor protein 2. (525 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.981
INSR
Insulin receptor.
    
 0.969
GRB2
Growth factor receptor bound protein 2.
    
 0.957
CBLB
Cbl proto-oncogene B.
    
 0.952
JAK2
Janus kinase 2.
    
 0.948
NTRK3
Neurotrophic receptor tyrosine kinase 3.
    
 0.920
NTRK2
Neurotrophic receptor tyrosine kinase 2.
    
 0.907
NTRK1
Neurotrophic receptor tyrosine kinase 1.
    
 0.894
INSRR
Insulin receptor related receptor.
    
 0.875
IGF1R
Insulin like growth factor 1 receptor.
    
 0.875
Your Current Organism:
Procavia capensis
NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax
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