Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)    
Predicted Functional Partners:
CRKL
CRK like proto-oncogene, adaptor protein.
    
 0.997
CRK
CRK proto-oncogene, adaptor protein.
    
 0.997
RAP1B
RAP1B, member of RAS oncogene family.
    
 0.984
CBL
Cbl proto-oncogene.
   
 0.971
GRB2
Growth factor receptor bound protein 2.
    
 0.970
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.937
EGFR
Epidermal growth factor receptor.
    
 0.931
CBLB
Cbl proto-oncogene B.
   
 0.928
RHOQ
Ras homolog family member Q.
    
 0.901
RHOJ
Ras homolog family member J.
    
 0.884
Your Current Organism:
Procavia capensis
NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax
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