Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BACE1Beta-secretase 1. (530 aa)    
Predicted Functional Partners:
APP
Amyloid beta precursor protein.
    
 0.997
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.974
RTN3
Reticulon 3.
    
 0.953
RTN4
Reticulon 4.
    
 0.942
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
    
 0.903
BACE2
Beta-secretase 2.
     
  0.863
APLP2
Amyloid beta precursor like protein 2.
    
 0.849
PSEN1
Presenilin 1.
    
 
 0.845
ENSPCAP00000006142
annotation not available
     
  0.840
APLP1
Amyloid beta precursor like protein 1.
    
 0.822
Your Current Organism:
Procavia capensis
NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax
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