Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXO1Forkhead box O1. (414 aa)    
Predicted Functional Partners:
SIRT1
Sirtuin 1.
    
 0.984
YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta.
    
 0.970
CREBBP
CREB binding protein.
   
 0.964
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
    
 0.960
AKT3
AKT serine/threonine kinase 3.
    
 0.959
AKT1
AKT serine/threonine kinase 1.
    
 0.959
CTNNB1
Catenin beta 1.
    
 0.952
MYC
MYC proto-oncogene, bHLH transcription factor.
   
 0.952
SGK2
Serum/glucocorticoid regulated kinase 2.
    
 0.946
SGK1
Serum/glucocorticoid regulated kinase 1.
    
 0.946
Your Current Organism:
Procavia capensis
NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax
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