node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1C1 | CYP17A1 | ENSSSCP00000042336 | ENSSSCP00000011283 | Aldo-keto reductase family 1 member C3 isoform 2. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.929 |
AKR1C1 | CYP2D25 | ENSSSCP00000042336 | ENSSSCP00000000051 | Aldo-keto reductase family 1 member C3 isoform 2. | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | 0.914 |
AKR1C1 | CYP7A1 | ENSSSCP00000042336 | ENSSSCP00000033898 | Aldo-keto reductase family 1 member C3 isoform 2. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] | 0.908 |
AKR1C1 | HSD3B1 | ENSSSCP00000042336 | ENSSSCP00000007165 | Aldo-keto reductase family 1 member C3 isoform 2. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.939 |
AKR1C1 | SULT2B1 | ENSSSCP00000042336 | ENSSSCP00000026787 | Aldo-keto reductase family 1 member C3 isoform 2. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.902 |
CAMSAP3 | CYP2D25 | ENSSSCP00000014434 | ENSSSCP00000000051 | Calmodulin regulated spectrin associated protein family member 3. | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | 0.721 |
CAMSAP3 | RNF207 | ENSSSCP00000014434 | ENSSSCP00000003652 | Calmodulin regulated spectrin associated protein family member 3. | RING finger protein 207. | 0.869 |
CYP17A1 | AKR1C1 | ENSSSCP00000011283 | ENSSSCP00000042336 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C3 isoform 2. | 0.929 |
CYP17A1 | CYP2D25 | ENSSSCP00000011283 | ENSSSCP00000000051 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | 0.917 |
CYP17A1 | CYP7A1 | ENSSSCP00000011283 | ENSSSCP00000033898 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] | 0.959 |
CYP17A1 | HSD3B1 | ENSSSCP00000011283 | ENSSSCP00000007165 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.993 |
CYP17A1 | SULT2B1 | ENSSSCP00000011283 | ENSSSCP00000026787 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.945 |
CYP2D25 | AKR1C1 | ENSSSCP00000000051 | ENSSSCP00000042336 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Aldo-keto reductase family 1 member C3 isoform 2. | 0.914 |
CYP2D25 | CAMSAP3 | ENSSSCP00000000051 | ENSSSCP00000014434 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Calmodulin regulated spectrin associated protein family member 3. | 0.721 |
CYP2D25 | CYP17A1 | ENSSSCP00000000051 | ENSSSCP00000011283 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.917 |
CYP2D25 | CYP7A1 | ENSSSCP00000000051 | ENSSSCP00000033898 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] | 0.956 |
CYP2D25 | HSD3B1 | ENSSSCP00000000051 | ENSSSCP00000007165 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.934 |
CYP2D25 | LOC100522849 | ENSSSCP00000000051 | ENSSSCP00000013929 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | 0.672 |
CYP2D25 | LOC100524300 | ENSSSCP00000000051 | ENSSSCP00000013932 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | 0.672 |
CYP2D25 | LOC110259250 | ENSSSCP00000000051 | ENSSSCP00000027543 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | 0.672 |