Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PPP1R11Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa)    
Predicted Functional Partners:
PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...]
   
 
 0.927
PPP1R7
Uncharacterized protein.
   
 
 0.907
PPP1CC
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 
 0.864
UBXN2B
UBX domain protein 2B.
   
 
 0.837
PPP1CA
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 
 0.834
PPP1R8
Protein phosphatase 1 regulatory subunit 8.
    
 
 0.800
PPP1R3A
Protein phosphatase 1 regulatory subunit 3A.
    
 
 0.786
VCP
Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...]
    
 
 0.766
PPP1R2
Uncharacterized protein.
    
 
 0.736
TIMD4
T cell immunoglobulin and mucin domain containing 4.
      
 0.734
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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