| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANPEP | CDO1 | ENSSSCP00000064055 | ENSSSCP00000015125 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Cysteine dioxygenase. | 0.919 |
| ANPEP | GCLC | ENSSSCP00000064055 | ENSSSCP00000001618 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Glutamate--cysteine ligase catalytic subunit isoform X3. | 0.948 |
| ANPEP | GCLM | ENSSSCP00000064055 | ENSSSCP00000040673 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Glutamate--cysteine ligase regulatory subunit. | 0.920 |
| ANPEP | GGT1 | ENSSSCP00000064055 | ENSSSCP00000030498 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.932 |
| ANPEP | GGT5 | ENSSSCP00000064055 | ENSSSCP00000059034 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Gamma-glutamyltransferase 5. | 0.925 |
| ANPEP | GGT6 | ENSSSCP00000064055 | ENSSSCP00000018943 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Gamma-glutamyltransferase 6. | 0.955 |
| ANPEP | GGT7 | ENSSSCP00000064055 | ENSSSCP00000007757 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Gamma-glutamyltransferase 7. | 0.940 |
| ANPEP | GSS | ENSSSCP00000064055 | ENSSSCP00000034338 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Glutathione synthetase. | 0.921 |
| ANPEP | LAP3 | ENSSSCP00000064055 | ENSSSCP00000061377 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | 0.963 |
| CDO1 | ANPEP | ENSSSCP00000015125 | ENSSSCP00000064055 | Cysteine dioxygenase. | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | 0.919 |
| CDO1 | GCLC | ENSSSCP00000015125 | ENSSSCP00000001618 | Cysteine dioxygenase. | Glutamate--cysteine ligase catalytic subunit isoform X3. | 0.955 |
| CDO1 | GCLM | ENSSSCP00000015125 | ENSSSCP00000040673 | Cysteine dioxygenase. | Glutamate--cysteine ligase regulatory subunit. | 0.934 |
| CDO1 | LAP3 | ENSSSCP00000015125 | ENSSSCP00000061377 | Cysteine dioxygenase. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | 0.919 |
| GCLC | ANPEP | ENSSSCP00000001618 | ENSSSCP00000064055 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] | 0.948 |
| GCLC | CDO1 | ENSSSCP00000001618 | ENSSSCP00000015125 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Cysteine dioxygenase. | 0.955 |
| GCLC | GCLM | ENSSSCP00000001618 | ENSSSCP00000040673 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Glutamate--cysteine ligase regulatory subunit. | 0.999 |
| GCLC | GGT1 | ENSSSCP00000001618 | ENSSSCP00000030498 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.952 |
| GCLC | GGT5 | ENSSSCP00000001618 | ENSSSCP00000059034 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Gamma-glutamyltransferase 5. | 0.936 |
| GCLC | GGT6 | ENSSSCP00000001618 | ENSSSCP00000018943 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Gamma-glutamyltransferase 6. | 0.966 |
| GCLC | GGT7 | ENSSSCP00000001618 | ENSSSCP00000007757 | Glutamate--cysteine ligase catalytic subunit isoform X3. | Gamma-glutamyltransferase 7. | 0.950 |
