Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CUL7Cullin-7 isoform X6; Belongs to the cullin family. (1691 aa)    
Predicted Functional Partners:
FBXW8
F-box and WD repeat domain containing 8.
   
 
 0.980
CUL9
Cullin 9; Belongs to the cullin family.
   
   0.953
RBX1
E3 ubiquitin-protein ligase RBX1.
   
 
 0.930
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 
 0.928
CCDC8
Coiled-coil domain-containing protein 8.
   
 
 0.921
MRPL16
39S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family.
  
 
 0.905
OBSL1
Obscurin-like protein 1 isoform X2.
   
 
 0.903
MRPL36
Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.
  
 
 0.898
MRPS11
Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.
  
 
 0.894
MRPL20
39S ribosomal protein L20, mitochondrial isoform 1; Belongs to the bacterial ribosomal protein bL20 family.
   
 
 0.893
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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