CRISP2 protein (Sus scrofa) - STRING interaction network

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CRISP2

Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family. (244 aa)

Predicted Functional Partners:

GART

0.803

ZNF706

0.764

PLCZ1

0.744

IZUMO1

0.719

F1SP87_PIG

0.649

FAM71D

0.639

CES5A

0.612

PRSS55

0.599

CD9

0.595

ACR

0.595

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACR	CD9	ENSSSCP00000042835	ENSSSCP00000026090	Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family.	CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]	0.629
ACR	CRISP2	ENSSSCP00000042835	ENSSSCP00000001893	Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family.	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	0.595
ACR	IZUMO1	ENSSSCP00000042835	ENSSSCP00000057796	Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family.	Izumo sperm-egg fusion 1.	0.808
CD9	ACR	ENSSSCP00000026090	ENSSSCP00000042835	CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]	Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family.	0.629
CD9	CRISP2	ENSSSCP00000026090	ENSSSCP00000001893	CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	0.595
CD9	IZUMO1	ENSSSCP00000026090	ENSSSCP00000057796	CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]	Izumo sperm-egg fusion 1.	0.849
CES5A	CRISP2	ENSSSCP00000036076	ENSSSCP00000001893	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	0.612
CRISP2	ACR	ENSSSCP00000001893	ENSSSCP00000042835	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family.	0.595
CRISP2	CD9	ENSSSCP00000001893	ENSSSCP00000026090	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]	0.595
CRISP2	CES5A	ENSSSCP00000001893	ENSSSCP00000036076	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.612
CRISP2	F1SP87_PIG	ENSSSCP00000001893	ENSSSCP00000005504	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Uncharacterized protein.	0.649
CRISP2	FAM71D	ENSSSCP00000001893	ENSSSCP00000073629	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Family with sequence similarity 71 member D.	0.639
CRISP2	GART	ENSSSCP00000001893	ENSSSCP00000025862	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.803
CRISP2	IZUMO1	ENSSSCP00000001893	ENSSSCP00000057796	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Izumo sperm-egg fusion 1.	0.719
CRISP2	PLCZ1	ENSSSCP00000001893	ENSSSCP00000000621	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...]	0.744
CRISP2	PRSS55	ENSSSCP00000001893	ENSSSCP00000010346	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	Serine protease 55; Belongs to the peptidase S1 family.	0.599
CRISP2	ZNF706	ENSSSCP00000001893	ENSSSCP00000068161	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	4F5 domain-containing protein.	0.764
F1SP87_PIG	CRISP2	ENSSSCP00000005504	ENSSSCP00000001893	Uncharacterized protein.	Cysteine-rich secretory protein 2 isoform X1; Belongs to the CRISP family.	0.649
F1SP87_PIG	IZUMO1	ENSSSCP00000005504	ENSSSCP00000057796	Uncharacterized protein.	Izumo sperm-egg fusion 1.	0.410
F1SP87_PIG	PLCZ1	ENSSSCP00000005504	ENSSSCP00000000621	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...]	0.497