node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO1 | ACO2 | ENSSSCP00000058798 | ENSSSCP00000000070 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | 0.928 |
ACO1 | CS | ENSSSCP00000058798 | ENSSSCP00000056310 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.997 |
ACO1 | GLUD1 | ENSSSCP00000058798 | ENSSSCP00000011056 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.587 |
ACO1 | GOT2 | ENSSSCP00000058798 | ENSSSCP00000055842 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.456 |
ACO1 | IDH1 | ENSSSCP00000058798 | ENSSSCP00000022058 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.990 |
ACO1 | IDH2 | ENSSSCP00000058798 | ENSSSCP00000036736 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. | 0.991 |
ACO1 | IDH3B | ENSSSCP00000058798 | ENSSSCP00000061140 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.972 |
ACO1 | IDH3G | ENSSSCP00000058798 | ENSSSCP00000062175 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.961 |
ACO1 | OGDH | ENSSSCP00000058798 | ENSSSCP00000017733 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Oxoglutarate dehydrogenase. | 0.587 |
ACO1 | OGDHL | ENSSSCP00000058798 | ENSSSCP00000036125 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | Oxoglutarate dehydrogenase like. | 0.431 |
ACO2 | ACO1 | ENSSSCP00000000070 | ENSSSCP00000058798 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Aconitase 1; Belongs to the aconitase/IPM isomerase family. | 0.928 |
ACO2 | CS | ENSSSCP00000000070 | ENSSSCP00000056310 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.999 |
ACO2 | GLUD1 | ENSSSCP00000000070 | ENSSSCP00000011056 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.481 |
ACO2 | GOT2 | ENSSSCP00000000070 | ENSSSCP00000055842 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.627 |
ACO2 | IDH1 | ENSSSCP00000000070 | ENSSSCP00000022058 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.992 |
ACO2 | IDH2 | ENSSSCP00000000070 | ENSSSCP00000036736 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. | 0.995 |
ACO2 | IDH3B | ENSSSCP00000000070 | ENSSSCP00000061140 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.994 |
ACO2 | IDH3G | ENSSSCP00000000070 | ENSSSCP00000062175 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.991 |
ACO2 | OGDH | ENSSSCP00000000070 | ENSSSCP00000017733 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Oxoglutarate dehydrogenase. | 0.920 |
ACO2 | OGDHL | ENSSSCP00000000070 | ENSSSCP00000036125 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. | Oxoglutarate dehydrogenase like. | 0.887 |