node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCN | FMOD | ENSSSCP00000000977 | ENSSSCP00000016193 | Decorin; May affect the rate of fibrils formation. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | 0.750 |
DCN | SMAD2 | ENSSSCP00000000977 | ENSSSCP00000054408 | Decorin; May affect the rate of fibrils formation. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.451 |
DCN | TGFB1 | ENSSSCP00000000977 | ENSSSCP00000030317 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.992 |
DCN | TGFB2 | ENSSSCP00000000977 | ENSSSCP00000035439 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.949 |
DCN | TGFB3 | ENSSSCP00000000977 | ENSSSCP00000030885 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.958 |
FMOD | DCN | ENSSSCP00000016193 | ENSSSCP00000000977 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | Decorin; May affect the rate of fibrils formation. | 0.750 |
FMOD | TGFB1 | ENSSSCP00000016193 | ENSSSCP00000030317 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.955 |
FMOD | TGFB2 | ENSSSCP00000016193 | ENSSSCP00000035439 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.925 |
FMOD | TGFB3 | ENSSSCP00000016193 | ENSSSCP00000030885 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.946 |
ITGAV | LTBP1 | ENSSSCP00000031102 | ENSSSCP00000036110 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Latent transforming growth factor beta binding protein 1. | 0.583 |
ITGAV | LTBP3 | ENSSSCP00000031102 | ENSSSCP00000056975 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Latent transforming growth factor beta binding protein 3. | 0.534 |
ITGAV | TGFB1 | ENSSSCP00000031102 | ENSSSCP00000030317 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.955 |
ITGAV | TGFB2 | ENSSSCP00000031102 | ENSSSCP00000035439 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.755 |
ITGAV | TGFB3 | ENSSSCP00000031102 | ENSSSCP00000030885 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.752 |
LTBP1 | ITGAV | ENSSSCP00000036110 | ENSSSCP00000031102 | Latent transforming growth factor beta binding protein 1. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.583 |
LTBP1 | LTBP3 | ENSSSCP00000036110 | ENSSSCP00000056975 | Latent transforming growth factor beta binding protein 1. | Latent transforming growth factor beta binding protein 3. | 0.549 |
LTBP1 | SMAD2 | ENSSSCP00000036110 | ENSSSCP00000054408 | Latent transforming growth factor beta binding protein 1. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.435 |
LTBP1 | TGFB1 | ENSSSCP00000036110 | ENSSSCP00000030317 | Latent transforming growth factor beta binding protein 1. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.981 |
LTBP1 | TGFB2 | ENSSSCP00000036110 | ENSSSCP00000035439 | Latent transforming growth factor beta binding protein 1. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.962 |
LTBP1 | TGFB3 | ENSSSCP00000036110 | ENSSSCP00000030885 | Latent transforming growth factor beta binding protein 1. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.939 |