node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AADAT | AGXT2 | ENSSSCP00000031451 | ENSSSCP00000034701 | Aminoadipate aminotransferase. | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.402 |
AADAT | BCAT2 | ENSSSCP00000031451 | ENSSSCP00000003396 | Aminoadipate aminotransferase. | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | 0.853 |
AGXT2 | AADAT | ENSSSCP00000034701 | ENSSSCP00000031451 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminoadipate aminotransferase. | 0.402 |
AGXT2 | BCAT2 | ENSSSCP00000034701 | ENSSSCP00000003396 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | 0.932 |
AGXT2 | BCKDHA | ENSSSCP00000034701 | ENSSSCP00000031128 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.823 |
AGXT2 | BCKDHB | ENSSSCP00000034701 | ENSSSCP00000069136 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Branched chain keto acid dehydrogenase E1 subunit beta. | 0.847 |
AGXT2 | CTH | ENSSSCP00000034701 | ENSSSCP00000004099 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.927 |
AGXT2 | GCLC | ENSSSCP00000034701 | ENSSSCP00000001618 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate--cysteine ligase catalytic subunit isoform X3. | 0.903 |
AGXT2 | GCLM | ENSSSCP00000034701 | ENSSSCP00000040673 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate--cysteine ligase regulatory subunit. | 0.903 |
BCAT2 | AADAT | ENSSSCP00000003396 | ENSSSCP00000031451 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Aminoadipate aminotransferase. | 0.853 |
BCAT2 | AGXT2 | ENSSSCP00000003396 | ENSSSCP00000034701 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.932 |
BCAT2 | BCKDHA | ENSSSCP00000003396 | ENSSSCP00000031128 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.992 |
BCAT2 | BCKDHB | ENSSSCP00000003396 | ENSSSCP00000069136 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Branched chain keto acid dehydrogenase E1 subunit beta. | 0.991 |
BCAT2 | CTH | ENSSSCP00000003396 | ENSSSCP00000004099 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.939 |
BCAT2 | FPGS | ENSSSCP00000003396 | ENSSSCP00000006027 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.855 |
BCAT2 | GCLC | ENSSSCP00000003396 | ENSSSCP00000001618 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Glutamate--cysteine ligase catalytic subunit isoform X3. | 0.900 |
BCAT2 | GCLM | ENSSSCP00000003396 | ENSSSCP00000040673 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Glutamate--cysteine ligase regulatory subunit. | 0.907 |
BCAT2 | IL4I1 | ENSSSCP00000003396 | ENSSSCP00000003464 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Amine oxidase. | 0.909 |
BCAT2 | LOC100525099 | ENSSSCP00000003396 | ENSSSCP00000036380 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). | Amine oxidase. | 0.900 |
BCKDHA | AGXT2 | ENSSSCP00000031128 | ENSSSCP00000034701 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.823 |