node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L1 | DAXX | ENSSSCP00000033436 | ENSSSCP00000001638 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] | Death domain associated protein. | 0.466 |
BCL2L1 | PARK7 | ENSSSCP00000033436 | ENSSSCP00000003670 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] | DJ-1 protein. | 0.921 |
BCL2L1 | PINK1 | ENSSSCP00000033436 | ENSSSCP00000003807 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] | PTEN induced kinase 1. | 0.939 |
DAXX | BCL2L1 | ENSSSCP00000001638 | ENSSSCP00000033436 | Death domain associated protein. | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] | 0.466 |
DAXX | MAP3K5 | ENSSSCP00000001638 | ENSSSCP00000034168 | Death domain associated protein. | Mitogen-activated protein kinase kinase kinase 5. | 0.979 |
DAXX | PARK7 | ENSSSCP00000001638 | ENSSSCP00000003670 | Death domain associated protein. | DJ-1 protein. | 0.925 |
MAP3K5 | DAXX | ENSSSCP00000034168 | ENSSSCP00000001638 | Mitogen-activated protein kinase kinase kinase 5. | Death domain associated protein. | 0.979 |
MAP3K5 | PARK7 | ENSSSCP00000034168 | ENSSSCP00000003670 | Mitogen-activated protein kinase kinase kinase 5. | DJ-1 protein. | 0.943 |
NFE2L2 | PARK7 | ENSSSCP00000064368 | ENSSSCP00000003670 | Nuclear factor, erythroid 2 like 2. | DJ-1 protein. | 0.934 |
NFE2L2 | SNCA | ENSSSCP00000064368 | ENSSSCP00000031954 | Nuclear factor, erythroid 2 like 2. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.422 |
NFE2L2 | SOD1 | ENSSSCP00000064368 | ENSSSCP00000026815 | Nuclear factor, erythroid 2 like 2. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.699 |
NFE2L2 | SOD2 | ENSSSCP00000064368 | ENSSSCP00000045952 | Nuclear factor, erythroid 2 like 2. | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.588 |
PARK7 | BCL2L1 | ENSSSCP00000003670 | ENSSSCP00000033436 | DJ-1 protein. | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] | 0.921 |
PARK7 | DAXX | ENSSSCP00000003670 | ENSSSCP00000001638 | DJ-1 protein. | Death domain associated protein. | 0.925 |
PARK7 | MAP3K5 | ENSSSCP00000003670 | ENSSSCP00000034168 | DJ-1 protein. | Mitogen-activated protein kinase kinase kinase 5. | 0.943 |
PARK7 | NFE2L2 | ENSSSCP00000003670 | ENSSSCP00000064368 | DJ-1 protein. | Nuclear factor, erythroid 2 like 2. | 0.934 |
PARK7 | PINK1 | ENSSSCP00000003670 | ENSSSCP00000003807 | DJ-1 protein. | PTEN induced kinase 1. | 0.904 |
PARK7 | PRKN | ENSSSCP00000003670 | ENSSSCP00000061874 | DJ-1 protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.837 |
PARK7 | SNCA | ENSSSCP00000003670 | ENSSSCP00000031954 | DJ-1 protein. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.879 |
PARK7 | SOD1 | ENSSSCP00000003670 | ENSSSCP00000026815 | DJ-1 protein. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.956 |