node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM83B | GFRAL | ENSSSCP00000001613 | ENSSSCP00000035293 | Family with sequence similarity 83 member B. | GDNF family receptor alpha like. | 0.700 |
FAM83B | HCRTR1 | ENSSSCP00000001613 | ENSSSCP00000037633 | Family with sequence similarity 83 member B. | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | 0.550 |
FAM83B | PEF1 | ENSSSCP00000001613 | ENSSSCP00000071901 | Family with sequence similarity 83 member B. | Penta-EF-hand domain containing 1. | 0.647 |
GFRAL | FAM83B | ENSSSCP00000035293 | ENSSSCP00000001613 | GDNF family receptor alpha like. | Family with sequence similarity 83 member B. | 0.700 |
GFRAL | HCRTR1 | ENSSSCP00000035293 | ENSSSCP00000037633 | GDNF family receptor alpha like. | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | 0.682 |
GFRAL | PEF1 | ENSSSCP00000035293 | ENSSSCP00000071901 | GDNF family receptor alpha like. | Penta-EF-hand domain containing 1. | 0.751 |
HCRT | HCRTR1 | ENSSSCP00000018447 | ENSSSCP00000037633 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | 0.972 |
HCRT | HCRTR2 | ENSSSCP00000018447 | ENSSSCP00000001611 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | 0.985 |
HCRT | OXR1 | ENSSSCP00000018447 | ENSSSCP00000032075 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). | Oxidation resistance protein 1 isoform 4. | 0.785 |
HCRT | PMCH | ENSSSCP00000018447 | ENSSSCP00000000917 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). | Pro-MCH preproprotein. | 0.943 |
HCRTR1 | FAM83B | ENSSSCP00000037633 | ENSSSCP00000001613 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Family with sequence similarity 83 member B. | 0.550 |
HCRTR1 | GFRAL | ENSSSCP00000037633 | ENSSSCP00000035293 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | GDNF family receptor alpha like. | 0.682 |
HCRTR1 | HCRT | ENSSSCP00000037633 | ENSSSCP00000018447 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). | 0.972 |
HCRTR1 | HCRTR2 | ENSSSCP00000037633 | ENSSSCP00000001611 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | 0.906 |
HCRTR1 | OXR1 | ENSSSCP00000037633 | ENSSSCP00000032075 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Oxidation resistance protein 1 isoform 4. | 0.610 |
HCRTR1 | PEF1 | ENSSSCP00000037633 | ENSSSCP00000071901 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Penta-EF-hand domain containing 1. | 0.611 |
HCRTR1 | PMCH | ENSSSCP00000037633 | ENSSSCP00000000917 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Pro-MCH preproprotein. | 0.536 |
HCRTR1 | RDH12 | ENSSSCP00000037633 | ENSSSCP00000002494 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.528 |
HCRTR1 | RDH8 | ENSSSCP00000037633 | ENSSSCP00000014529 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.584 |
HCRTR1 | UBR3 | ENSSSCP00000037633 | ENSSSCP00000016891 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.515 |